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Huan Qiao, Ph.D.

Research Instructor, Lovly Lab

Research Description

I am working to study mechanisms of acquired resistance to ALK tyrosine kinase inhibitors (TKIs) in lung cancer. In particular, I am now  focusing on a novel association between ALK and the EGFR/HER2 negative regulator, MIG-6. My work will dissect how ALK fusions regulate MIG-6, and therefore EGFR/HER2, in the ALK TKI sensitive state, and how this regulation is altered at the time of ALK TKI resistance.



1. Qiao, H, Liu, Y, Veach, RA, Wylezinski, L, Hawiger, J. The Adaptor CRADD/RAIDD Controls Activation of Endothelial Cells by Proinflammatory Stimuli. Journal of Biological Chemistry. (2014), 289(32):21973-83 PMCID: PMC4139214

2. Qiao, H, Lovly, CM. Cracking the Code of Resistance across Multiple Lines of ALK Inhibitor Therapy in Lung Cancer. Cancer Discov. (2016) 6(10):1084-1086.