W. Kimryn Rathmell, M.D., Ph.D.
Professor and Chair, Department of Medicine; Director, Division of Hematology and Oncology; Professor of Biochemistry; Hugh J. Morgan Chair in Medicine
- : kimryn.rathmell@vumc.org
- : 615-936-842
- :
798c Preston Research Building
2220 Pierce Ave
Nashville, - 37232-6307
The Rathmell Lab focuses on investigations into the underlying molecular drivers of kidney tumors. Our goal is to identify strategies to improve the treatment of cancers based on biomarker approaches to defining drivers of the cancer phenotype, or developing better ways to detect these cancers earlier.
RECENT PUBLICATIONS:
- Ligand-independent integrin beta1 signaling supports lung adenocarcinoma development. Haake SM, Plosa EJ, Kropski JA, Venton LA, Reddy A, Bock F, Chang BT, Luna AJ, Nabukhotna K, Xu ZQ, Prather RA, Lee S, Tanjore H, Polosukhin VV, Viquez OM, Jones A, Luo W, Wilson MH, Rathmell WK, Massion PP, Pozzi A, Blackwell TS, Zent R. JCI Insight. 2022 Jun 28:e154098. doi: 10.1172/jci.insight.154098. Online ahead of print.PMID: 35763345 Free article.
- Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline. Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA. J Clin Oncol. 2022 Jun 21:JCO2200868. doi: 10.1200/JCO.22.00868. Online ahead of print.PMID: 35728020
- Mutation and tissue lineage lead to organ-specific cancer. Arner EN, Rathmell WK. Nature. 2022 Jun;606(7916):871-872. doi: 10.1038/d41586-022-01535-z.PMID: 35676353 No abstract available.
- Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer. Glass EB, Hoover AA, Bullock KK, Madden MZ, Reinfeld BI, Harris W, Parker D, Hufnagel DH, Crispens MA, Khabele D, Rathmell WK, Rathmell JC, Wilson AJ, Giorgio TD, Yull FE. BMC Cancer. 2022 May 6;22(1):497. doi: 10.1186/s12885-022-09612-2.PMID: 35513776 Free PMC article.
- Pearls of wisdom for aspiring physician-scientist residency applicants and program directors.Gallagher EJ, Rockey DC, Kontos CD, Vyas JM, Brass LF, Hu PJ, Isales CM, Ajijola OA, Rathmell WK, Conlin PR, Baiocchi RA, Kazmierczak BI, Akabas MH, Williams CS.JCI Insight. 2022 Mar 22;7(6):e158467. doi: 10.1172/jci.insight.158467.PMID: 35315364 Free PMC article.
- From Basic Science to Clinical Translation in Kidney Cancer: A Report from the Second Kidney Cancer Research Summit. Choueiri TK, Albiges L, Atkins MB, Bakouny Z, Bratslavsky G, Braun DA, Haas NB, Haanen JBAG, Hakimi AA, Jewett MAS, Jonasch E, Kaelin WG, Kapur P, Labaki C, Lewis B, McDermott DF, Pal SK, Pels K, Poteat S, Powles T, Rathmell WK, Rini BI, Signoretti S, Tannir NM, Uzzo RG, Hammers HJ. Clin Cancer Res. 2022 Mar 1;28(5):831-839. doi: 10.1158/1078-0432.CCR-21-3238.PMID: 34965942 Free PMC article.
- Spatial models of tumour evolution. Gaines DK, Rathmell WK. Nat Ecol Evol. 2022 Jan;6(1):26-27. doi: 10.1038/s41559-021-01584-z.PMID: 34949818 No abstract available.
- Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase.Reisman BJ, Guo H, Ramsey HE, Wright MT, Reinfeld BI, Ferrell PB, Sulikowski GA, Rathmell WK, Savona MR, Plate L, Rubinstein JL, Bachmann BO. Nat Chem Biol. 2022 Apr;18(4):360-367. doi: 10.1038/s41589-021-00900-9. Epub 2021 Dec 2.PMID: 34857958 Free PMC article.
- Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease. Jonasch E, Donskov F, Iliopoulos O, Rathmell WK, Narayan VK, Maughan BL, Oudard S, Else T, Maranchie JK, Welsh SJ, Thamake S, Park EK, Perini RF, Linehan WM, Srinivasan R; MK-6482-004 Investigators. N Engl J Med. 2021 Nov 25;385(22):2036-2046. doi: 10.1056/NEJMoa2103425.PMID: 34818478 Clinical Trial.
- Upcycling the TCA cycle-rewiring tumour-associated fibroblasts. Bacigalupa ZA, Rathmell WK. Nat Metab. 2021 Nov;3(11):1439-1440. doi: 10.1038/s42255-021-00473-w.PMID: 34764458 No abstract available.
View All Dr. Rathmell’s Publications in PubMed in the below link: https://pubmed.ncbi.nlm.nih.gov/?term=%28Rathmell+WK%5Bauthor%5D%29&sort=date&size=200