Zhenfang Du, Ph.D.
Research Fellow, Lovly Lab, Division of Hematology/Oncology
Research Description
My research is mainly concentrated on the identification of novel molecular cohorts of lung cancer with EGFR alterations, and the mechanistic investigation of acquired therapeutic resistance to tyrosine kinase inhibitors in the treatment of EGFR-mutant lung cancer.
Publications
Du Z, Lovly CM. Mechanisms of receptor tyrosine kinase activation in cancer. Mol Cancer. 2018 Feb 19;17(1):58.
Du Z, Gallant JN, Sheehan J, Meiler J, Lovly CM. Intramolecular dimerization of EGFR kinase domain duplication as a novel activation mechanism. J Thorac Oncol. 2017 Aug; 12(8): S1536.
My research mainly concentrated on the identification of novel molecular cohorts of lung cancer with EGFR alterations, and the investigation of acquired therapeutic resistance to tyrosine kinase inhibitors in the treatment of lung cancer.