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It is a great pleasure for me to announce the arrival of Marija Zanic, Ph.D., who will be joining the Department of Cell and Developmental Biology as an Assistant Professor on August 1, 2014.  Trained as a theoretical physicist and cytoskeleton biologist, Marija will add a quantitative flair and computational… Read More

CLASPs Are Required for Proper Microtubule Localization of End-Binding Proteins   Ashley D. Grimaldi1, Takahisa Maki2, Benjamin P. Fitton4, Daniel Roth4, Dmitry Yampolsky1, Michael W. Davidson3, Tatyana Svitkina5, Anne Straube4, Ikuko Hayashi2, Irina Kaverina Summary Microtubule (MT) plus-end tracking proteins (+TIPs) preferentially localize to MT plus ends. End-binding proteins (EBs)… Read More

Macrophages Promote Progression of Spasmolytic Polypeptide-Expressing Metaplasia After Acute Loss of Parietal Cells Petersen CP1, Weis VG1, Nam KT2, Sousa JF3, Fingleton B4, Goldenring JR5. Gastroenterology. 2014 Jun;146(7):1727-38.e8. doi: 10.1053/j.gastro.2014.02.007. Epub 2014 Feb 15. Abstract BACKGROUND & AIMS: Loss of parietal cells causes the development of spasmolytic… Read More

Working with Billy Hudson's lab in the department of medicine, the Page-McCaw lab determined that the element bromine is required for crosslinking basement membrane, the extracellular matrix underlying all epithelial tissues.  Without bromine, the basement membrane is weakened and fruitflies cannot survive.  As this basement-membrane crosslink is highly conserved throughout… Read More

Working with Billy Hudson's lab in the department of medicine, the Page-McCaw lab determined that the element bromine is required for crosslinking basement membrane, the extracellular matrix underlying all epithelial tissues.  Without bromine, the basement membrane is weakened and fruitflies cannot survive.  As this basement-membrane crosslink is highly conserved throughout… Read More

John H. Exton Award for Research Leading to Innovative Biological Concepts — Matthew J. Tyska, Ph.D., Associate Professor of Cell and Developmental Biology Tyska earned his Bachelor of Science degree in Biology at the University of Notre Dame, and his Ph.D. in Molecular Physiology and Biophysics at the… Read More

The Par3-like polarity protein Par3L is essential for mammary stem cell maintenance.a Yongliang Huo & Ian G. Macara Nature Cell Biology 16, 529–537 (2014) doi:10.1038/ncb2969 Received 01 August 2013, Accepted 11 April 2014, Published online 25 May 2014, Corrected online 30 May 2014 Abstract The Par polarity… Read More

Casein kinase II Regulation of the Hot1 Transcription Factor Promotes Stochastic Gene Expression Laura T. Burns and Susan R. Wente   Capsule Background: Dynamic signaling events are required for cell-to-cell gene expression differences during responses to environmental stress. Results: During hyperosmotic stress, casein kinase… Read More

Kinetochore-microtubule stability governs the metaphase requirement for Eg5 A. Sophia Gayek1 and Ryoma Ohi1, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232 Kerry Bloom, Monitoring Editor Submitted March 3, 2014, Revised April 28, 2014, Accepted May 1, 2014. Abstract  … Read More

Mol Biol Cell. 2014 Mar;25(6):800-10. doi: 10.1091/mbc.E13-07-0374. Epub 2014 Jan29. Microtubule segment stabilization by RASSF1A is required for proper microtubule dynamics and Golgi integrity. Arnette C(1), Efimova N, Zhu X, Clark GJ, Kaverina I. Author information: (1)Department of Cell and Developmental Biology, Vanderbilt University Medical… Read More