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  Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system.   Jao LE, Wente SR, Chen W.   Source Department of Cell and Developmental Biology and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-8240.   Abstract A… Read More

Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the Integrator complex Jeanne N. Jodoina, Poojitha Sitarama, Todd R. Albrechtb,… Read More

This award recognizes faculty members for excellence in research, scholarship or creative expression. Dr. Casagrande won this award for a ground-breaking paper in Nature Neuroscience, in which a novel linkage was identified between primary visual cortex of the brain and the thalamus, which controls the ability of the visual system… Read More

The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors Jonathan T. Fleming, Wenjuan He, Chuanming Hao, Tatiana Ketova, Fong C. Pan, Christopher C.V. Wright, Ying Litingtung, Chin Chiang Highlights •Purkinje neurons signal bidirectionally to expand functionally divergent cell types •Nascent white matter… Read More

The Purkinje Neuron Acts as a Central Regulator of Spatially and Functionally Distinct Cerebellar Precursors Jonathan T. Fleming, Wenjuan He, Chuanming Hao, Tatiana Ketova, Fong C. Pan, Christopher C.V. Wright, Ying Litingtung, Chin Chiangemail DOI: http://dx.doi.org/10.1016/j.devcel.2013.10.008     Highlights   •Purkinje… Read More

Targeting the Wnt Pathway in Synovial Sarcoma Models Whitney Barham1, Andrea L. Frump5, Taylor P. Sherrill3, Christina B. Garcia7, Kenyi Saito-Diaz5, Michael N. VanSaun2, Barbara Fingleton1, Linda Gleaves3, Darren Orton6, Mario R. Capecchi8, Timothy S. Blackwell3, Ethan Lee4,5, Fiona Yull1 and Josiane E. Eid1 Abstract Synovial sarcoma… Read More

Summary The conserved multifunctional protein Gle1 regulates gene expression at multiple steps: nuclear mRNA export, translation initiation, and translation termination. A GLE1 mutation (FinMajor) is causally linked to human lethal congenital contracture syndrome-1 (LCCS1); however, the resulting perturbations on Gle1 molecular function were unknown. FinMajor results in a… Read More

Retinotopic maps in the pulvinar of bush baby (otolemur garnettii) K. Li1, J. Patel2, G. Purushothaman2, R.T. Marion3 andV.A. Casagrande1,2,3,4,* Article first published online: 23 AUG 2013 DOI: 10.1002/cne.23358 Abstract Despite its anatomical prominence, the function of the primate pulvinar is poorly understood. A few electrophysiological studies in… Read More

CK1 is required for a mitotic checkpoint that delays cytokinesis Alyssa E. Johnson, Jun-Song Chen, Kathleen L. Gould Highlights •Dma1’s FHA domain binds to a pTXXpS phosphomotif on Sid4 •CK1 is required for Dma1-dependent Sid4 ubiquitination •CK1 phosphorylation of Sid4 is required for the Dma1-dependent mitotic checkpoint… Read More