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SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis K. Adam Bohnert1, Agnieszka P. Grzegorzewska2,3,6, Alaina H. Willet1, Craig W. Vander Kooi4,5, David R. Kovar2,3 and Kathleen L. Gould1,7 Abstract Many eukaryotes accomplish cell division by building and constricting a medial actomyosin-based cytokinetic ring (CR). In Schizosaccharomyces pombe,… Read More

A Generalized ideal observer model for decoding sensory neural responses Gopathy Purushothaman and Vivien A. Casagrande  Front. Psychol., 19 September 2013 | doi: 10.3389/fpsyg.2013.00617 Abstract We show that many ideal observer models used to decode neural activity can be generalized to a conceptually and analytically simple form. Read More

A simple and robust method for targeted mutagenesis in zebrafish has long been sought. Previous methods generate monoallelic mutations in the germ line of F0 animals, usually delaying homozygosity for the mutation to the F2 generation. Generation of robust biallelic mutations in the F0 would allow for phenotypic analysis directly… Read More

I am very pleased to announce the appointment of Jason MacGurn, Ph.D., to the rank of Assistant Professor of Cell and Developmental Biology on the tenure track, effective August 1, 2013. Jason is currently a Post Doctoral Fellow in Scott Emr’s Lab at Cornell University Weill Institute for Cell and… Read More

Mol Cell Proteomics. 2013 May;12(5):1074-86. doi: 10.1074/mcp.M112.025924. Epub 2013 Jan 7. Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase. Chen JS, Broadus MR, McLean JR, Feoktistova A, Ren L, Gould KL.   ‡Howard Hughes Medical Institute and Department of Cell and Developmental… Read More

The Scribble polarity protein stabilizes E-cadherin/p120-catenin binding and blocks retrieval of E-cadherin to the Golgi. Lohia M, Qin Y, Macara IG. Source Department of Microbiology, Ctr for Cell Signaling, University of Virginia School of Medicine, Charlottesville, VA, USA. Abstract Several polarity proteins, including Scribble (Scrb) have been implicated… Read More

Jodoin JN, Shboul M, Sitaram P, Zein-Sabatto H, Reversade B, Lee E, Lee LA. Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232-8240, USA. Abstract Recruitment of dynein motors to the nuclear surface is an essential step for nucleus-centrosome coupling in prophase. In cultured human cells,… Read More

Cell & Developmental Biology welcomes new faculty member Ken Lau, Ph.D. Dr. Ken Lau comes to Vanderbilt after completing his post postdoctorate training in the laboratory of Kenvi Hargis, Ph.D. In the Molecular Pathology Unit at the Massachusetts General Hospital and Harvard Medical School. Dr. Lau was chosen to join… Read More

Ian G. Macara, Ph.D. Louise B. McGavock and Chair, Department of Cell and Developmental Biology Vanderbilt University Medical School Mary Heath, MBA, CFA, CRA, will assume the position of Departmental Administrator in the Department of Cell and Developmental Biology on April 22, 2013. Ms. Heath will be… Read More

Morphological and neurochemical comparisons between pulvinar and V1 projections to V2 Roan Marion1, Keji Li2, Gopathy Purushothaman3, Yaoguang Jiang2 andVivien A. Casagrande1 Article first published online: 22 JAN 2013 DOI: 10.1002/cne.23203 Abstract The flow of visual information is clear at the earliest stages: the retina provides… Read More