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Context-specific α-to-β-cell reprogramming by forced Pdx1 expression Yu-Ping Yang1,Fabrizio Thorel2,Daniel F. Boyer1,Pedro L. Herrera2 and Christopher V.E. Wright1,3 1Vanderbilt University Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA; 2Department of Cell Physiology and Metabolism, University of Geneva Faculty of… Read More

eural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates Nathan A. Mundell1,2,3 and Patricia A. Labosky1,2,3,4,* 1 Center for Stem Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0494, USA. 2 Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN… Read More

EMBO J. 2011 Jan 19;30(2):341-54. Epub 2010 Dec 3. Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase. Johnson AE, Gould KL. Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. Abstract Proper cell division requires strict coordination between mitotic… Read More

Casagrande’s contributions to anatomical science honored BY: BILL SNYDER 2/10/2011 – Vivien Casagrande, Ph.D., professor of Cell & Developmental Biology at Vanderbilt University, has been named a fellow of the American Association of Anatomists. Vivien Casagrande, Ph.D. The honor recognizes “excellence in science and in … overall contributions to… Read More

Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation Received 30 June 2010; revised 27 October 2010;  accepted 5 November 2010.  Available online 14 November 2010. Abstract Interactions between cells from the ectoderm and mesoderm influence development of… Read More

Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Sparks EE, Perrien DS, Huppert KA, Peterson TE, Huppert SS. Department of Cell and Developmental Biology and Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Abstract… Read More

Cardiac neural crest development requires genetic interaction between the transcription factors Foxd3 and Pax3 Abstract The transcription factors Foxd3 and Pax3 are important early regulators of neural crest (NC) progenitor cell properties. Homozygous mutations of Pax3 or a homozygous NC-specific deletion of Foxd3 cause marked defects in most… Read More

Labosky named to direct Office of Postdoctoral Affairs BY: BILL SNYDER 1/06/2011 – Patricia Labosky, Ph.D., associate professor of Cell & Developmental Biology and of Pharmacology, has been named director of the Office of Postdoctoral Affairs at Vanderbilt University Medical Center. Patricia Labosky, Ph.D. Labosky succeeds Ann Richmond, Ph.D., professor… Read More

Cdc14B phosphatase contributes to ciliogenesis in zebrafish Development. 2011 Jan;138(2):291-302. Clément A, Solnica-Krezel L, Gould KL. Howard Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine Abstract Progression through the cell cycle relies on oscillation of cyclin-dependent kinase (Cdk) activity. One mechanism… Read More

Rapid differential transport of Nodal and Lefty on sulfated proteoglycan-rich extracellular matrix regulates left-right asymmetry in Xenopus Lindsay Marjoram and Christopher Wright Department of Cell and Developmental Biology, Program in Developmental Biology, Vanderbilt University Medical School, Nashville, TN 37232, USA. Author for correspondence (chris.wright@vanderbilt.edu) Summary The spatiotemporally dynamic distribution of… Read More