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In humans, GLE1 is mutated in lethal congenital contracture syndrome 1 (LCCS1) leading to prenatal death of all affected fetuses. Although the molecular roles of Gle1 in nuclear mRNA export and translation have been documented, no animal models for this disease have been reported. To elucidate the function of Gle1… Read More

One of the most abundant components of the enterocyte brush border is the actin-based monomeric motor, myosin-1a (Myo1a). Within brush border microvilli, Myo1a carries out a number of critical functions at the interface between membrane and actin cytoskeleton. Proper physiological function of Myo1a depends on its ability to bind to… Read More

"In November 2011, the AAAS Council elected 539 members as Fellows of AAAS. These individuals will be recognized for their contributions to science and technology at the Fellows Forum to be held on 18 February 2012 during the AAAS Annual Meeting in Vancouver, Canada. The new Fellows will receive a… Read More

Jun-Song Chen1,2, Lucy X. Lu1,2, Melanie D. Ohi2, Kevin M. Creamer3,4, Chauca English2,  Janet F. Partridge4, Ryoma Ohi2, and Kathleen L. Gould1,2 1 Howard Hughes Medical Institute & 2 Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37212 3 Integrated Program in Biomedical… Read More

Author contributions: S.C.P., J.D.W., J.E.R., and D.M.M. designed research; S.C.P., J.D.W., and J.E.R. performed research; M.S. and W.W.W. contributed unpublished reagents/analytic tools; S.C.P., J.D.W., J.E.R., and D.M.M. analyzed data; S.C.P. and D.M.M. wrote the paper. Abstract Although transcription factors are known to regulate synaptic plasticity, downstream genes that contribute… Read More

Jennifer Plank, a current student in Cell and Developmental Biology, received the award in the graduate student category. Working with Patricia Labosky, Ph.D., Jennifer studies regulators of pancreatic beta cell mass expansion. She has identified important roles for the neural crest and for the transcription factor Foxd3 in the beta… Read More

Susan Wente, Associate Vice Chancellor for Research, Senior Associate Dean for Biomedical Sciences, and Professor, Cell and Developmental Biology, Vanderbilt University School of Medicine, was named by the ASCB’s Women in Cell Biology (WICB) Committee to receive the 2011 WICB… Read More

Jennifer L. Plank, Audrey Y. Frist, Alison W. LeGrone, Mark A. Magnuson and Patricia A. Labosky – Author Affiliations Department of Cell and Developmental Biology (J.L.P., A.Y.F., A.W.L., M.A.M., P.A.L.), Center for Stem Cell Biology (J.L.P., A.Y.F., A.W.L., M.A.M., P.A.L.), Program in Developmental Biology (J.L.P., A.Y.F., A.W.L., M.A.M., P.A.L.), Department… Read More

Genetic interactions between hepatocyte nuclear factor-6 and notch signaling regulate mouse intrahepatic bile duct development in vivo Charles Vanderpool1, Erin E. Sparks2, Kari A. Huppert2, Maureen Gannon3, Anna L. Means4, Stacey S. Huppert2,*,† DOI: 10.1002/hep.24631 Abstract Notch signaling and hepatocyte nuclear factor-6 (HNF-6) are two genetic factors known… Read More

A Tethering Mechanism Controls the Processivity and Kinetochore-Microtubule Plus-End Enrichment of the Kinesin-8 Kif18A Jason Stumpff2, 4, Yaqing Du1, 4, Chauca A. English1, Zoltan Maliga3, Michael Wagenbach2, Charles L. Asbury2, Linda Wordeman2, 4, ,  and Ryoma Ohi1, 4, 1 Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, 37232… Read More