Uncategorized

Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site. Roberts-Galbraith RH, Ohi MD, Ballif BA, Chen JS, McLeod I, McDonald WH, Gygi SP, Yates JR 3rd, Gould KL. Howard Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt University… Read More

Structural organization of the functional domains of Clostridium difficile toxins A and B Rory N. Pruitta, Melissa G. Chambersb, Kenneth K.-S. Ngc, Melanie D. Ohib,1, and D. Borden Lacya,d,1 + Author Affiliations Departments of aMicrobiology and Immunology, bCell and Developmental Biology, and dBiochemistry, Vanderbilt University School… Read More

Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans. Smith CJ, Watson JD, Spencer WC, O'Brien T, Cha B, Albeg A, Treinin M, Miller DM 3rd. Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232-8240, USA. Read More

Coenzyme Q protects Caenorhabditis elegans GABA neurons from calcium-dependent degeneration. Earls LR, Hacker ML, Watson JD, Miller DM 3rd. Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232-8240, USA. Abstract Mitochondria are key regulators of cell viability and provide essential functions that protect against neurodegenerative disease. Read More

On July 1 this year Associate Professor Andrea Page–McCaw will join us. Andrea studies protease-mediated cell signaling and tissue remodeling in Drosophila, and comes to us from the Rensselaer Polytechnic Institute in NY. Andrea’s lab and office will be located in 4124 MRB III. Research Interests Protease-mediated cell-cell… Read More

Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice Erin E. Sparks 1, Kari A. Huppert 1, Melanie A. Brown 1, M. Kay Washington 2, Stacey S. Huppert 1 * 1Department of Cell and Developmental Biology and Center for Stem Cell Biology, Vanderbilt… Read More

Sci. Signal., 11 May 2010 Vol. 3, Issue 121, p. ra37 [DOI: 10.1126/scisignal.2000647] RESEARCH Gβ Activates GSK3 to Promote LRP6-Mediated β-Catenin Transcriptional Activity Kristin K. Jernigan1*, Christopher S. Cselenyi1*, Curtis A. Thorne1, Alison J. Hanson1, Emilios Tahinci1, Nicole Hajicek2,3, William M. Oldham4, Laura A. Lee1, Heidi E. Hamm4,… Read More

Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development Xi Huanga, Jiang Liua, Tatiana Ketovaa, Jonathan T. Fleminga, Vandana K. Groverb, Michael K. Cooperb, Ying Litingtunga, and Chin Chianga,1 + Author Affiliations Departments of aCell and Developmental Biology and bNeurology, Center for Molecular Neuroscience,… Read More

P.Ohi lab’s first paper hit the press today in Current Biology, this issue The Kinesin-8 Kif18A Dampens Microtubule Plus-End Dynamics Yaqing Du1, Chauca A. English1 and Ryoma Ohi 1 Department of Cell and DevelopmentalBiology, Vanderbilt University School of Medicine, 465 21st AvenueSouth, Nashville, TN 37232-8240, USA Received 2… Read More

Dear Colleagues, As 2009 comes to a close, I would like to take this opportunity to wish you well and to announce these important changes for senior leadership within the departments of Cell and Developmental Biology and Cancer Biology. These changes are effective January 1. First, I would like to… Read More