The goal of my research is to understand the transcriptional mechanisms underpinning the JAK-STAT signaling pathway that lead to human disease and cancer.
A fundamental question in molecular biology is how human disease is programmed into the genome. The overarching goal of my laboratory is to elucidate the transcription regulatory networks underlying oncogenic signaling pathways. STAT transcription factors in the JAK-STAT pathway (Janus Kinase-Signal Transducer and Activator of Transcription) are among the most frequently activated oncogenic proteins in cancer cells. My current research is focused on discovering how the JAK-STAT pathway is involved in the disease process using genetic, molecular, and next-gen sequencing approaches.
The goals of some current projects in my laboratory are to:
- Understand how STATs direct aberrant transcriptional programs in leukemia using stat-of-the-art functional genomics approaches
- Dissect the functional interdependencies among STATs on a genome-wide scale
- Identifying regulatory complexes that are recruited by the STAT transcription factors
- Discover novel molecular signatures in clinical samples with the future goal to better predict patient prognosis and identify new therapeutic targets