Brain function relies on the formation and stabilization of synapses, and many neurological disorders are associated with disruptions in synaptic signaling. Scaffolding proteins play a critical role in maintaining spine morphology and bringing receptors and ion channels in close proximity to their downstream signaling molecules. In the Colbran lab, I study protein-protein interactions between CaMKII and scaffolds in the postsynaptic spines of neurons, and how they regulate downstream signaling. I am also interested in how neurons signal from the synapse to the nucleus in order to initiate gene transcription, an important process in learning and memory.
BA, DePauw University