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Molecular Physiology & Biophysics

Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell cytokine production in vivo.

AUTHORS

Toki S , Goleniewska K , Reiss S , Zhang J , Bloodworth MH , Stier MT , Zhou W , Newcomb DC , Ware LB , Stanwood GD , Galli A , Boyd KL , Niswender KD , Peebles RS , . The Journal of allergy and clinical immunology. 2018 1 10; ().

ABSTRACT

IL-33 is one of the most consistently associated gene candidates for asthma identified by using a genome-wide association study. Studies in mice and in human cells have confirmed the importance of IL-33 in inducing type 2 cytokine production from both group 2 innate lymphoid cells (ILC2s) and T2 cells. However, there are no pharmacologic agents known to inhibit IL-33 release from airway cells.

IL-33 is one of the most consistently associated gene candidates for asthma identified by using a genome-wide association study. Studies in mice and in human cells have confirmed the importance of IL-33 in inducing type 2 cytokine production from both group 2 innate lymphoid cells (ILC2s) and T2 cells. However, there are no pharmacologic agents known to inhibit IL-33 release from airway cells.

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