The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice.
AUTHORS
Spaeth
JM ,
Hunter
CS ,
Bonatakis
L ,
Guo
M ,
French
CA ,
Slack
I ,
Hara
M ,
Fisher
SE ,
Ferrer
J ,
Morrisey
EE ,
Stanger
BZ ,
Stein
R ,
. Diabetologia. 2015 8 ; 58(8). 1836-44
- PMID: 26021489 [PubMed].
- PMCID: PMC4785827.
- NIHMSID: NIHMS765277
ABSTRACT
Several forkhead box (FOX) transcription factor family members have important roles in controlling pancreatic cell fates and maintaining beta cell mass and function, including FOXA1, FOXA2 and FOXM1. In this study we have examined the importance of FOXP1, FOXP2 and FOXP4 of the FOXP subfamily in islet cell development and function.
Several forkhead box (FOX) transcription factor family members have important roles in controlling pancreatic cell fates and maintaining beta cell mass and function, including FOXA1, FOXA2 and FOXM1. In this study we have examined the importance of FOXP1, FOXP2 and FOXP4 of the FOXP subfamily in islet cell development and function.
Tags: 2015