Self-Assessed Severity as a Determinant of COVID-19 Symptom Specificity: A Longitudinal Cohort Study
AUTHORS
Bershteyn
A ,
Dahl
AM ,
Dong
TQ ,
Deming
ME ,
Celum
CL ,
Chu
HY ,
Kottkamp
AC ,
Greninger
AL ,
Hoffman
RM ,
Jerome
KR ,
Johnston
CM ,
Kissinger
PJ ,
Landovitz
RJ ,
Laufer
MK ,
Luk
A ,
Neuzil
KM ,
Paasche-Orlow
MK ,
Pitts
RA ,
Schwartz
MD ,
Stankiewicz Karita
HC ,
Thorpe
LE ,
Wald
A ,
Zheng
CY ,
Wener
MH ,
Barnabas
RV ,
Brown
ER ,
. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 2 13; ().
- PMID: 35152299 [PubMed].
ABSTRACT
COVID-19 symptom definitions rarely include symptom severity. We collected daily nasal swabs and symptom diaries from contacts of SARS-CoV-2 cases. Requiring ≥1 moderate or severe symptom reduced sensitivity to predict SARS-CoV-2 shedding from 60.0% (CI: 52.9-66.7%) to 31.5% (CI: 25.7-38.0%), but increased specificity from 77.5% (CI:75.3-79.5%) to 93.8% (CI: 92.7-94.8%).
Tags: alumni publications 2022, faculty publications 2022