Durable anti-Vi IgG and IgA antibody responses in 15-month-old children vaccinated with typhoid conjugate vaccine in Burkina Faso
AUTHORS
Ouedraogo
A ,
Diarra
A ,
Nébié
I ,
Barry
N ,
Kabore
JM ,
Tiono
AB ,
Datta
S ,
Liang
Y ,
Mayo
I ,
Oshinsky
J ,
Tracy
JK ,
Girmay
T ,
Pasetti
M ,
Jamka
LP ,
Neuzil
KM ,
Sirima
SB ,
Laurens
MB ,
. Journal of the Pediatric Infectious Diseases Society. 2023 8 17; ().
- PMID: 37589596 [PubMed].
ABSTRACT
We assessed anti-Vi IgG/IgA responses to typhoid conjugate vaccine (TCV) in children enrolled in a double-blind randomized, controlled, phase 2 trial in Burkina Faso. Anti-Vi IgG seroconversion and anti-Vi IgA titers were higher in TCV than control recipients at 30-35 months post-vaccination. TCV induces durable immunity in Burkinabe children vaccinated at 15-months.
Tags: 2023 Alumni Publications