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Master of Public Health

Hypertension is associated with preamyloid oligomers in human atrium: a missing link in atrial pathophysiology?

AUTHORS

Sidorova TN , Mace LC , Wells KS , Yermalitskaya LV , Su PF , Shyr Y , Atkinson JB , Fogo AB , Prinsen JK , Byrne JG , Petracek MR , Greelish JP , Hoff SJ , Ball SK , Glabe CG , Brown NJ , Barnett JV , Murray KT , . Journal of the American Heart Association. 2014 ; 3(6).
  • NIHMSID: 101580524

ABSTRACT

Increasing evidence indicates that proteotoxicity plays a pathophysiologic role in experimental and human cardiomyopathy. In organ-specific amyloidoses, soluble protein oligomers are the primary cytotoxic species in the process of protein aggregation. While isolated atrial amyloidosis can develop with aging, the presence of preamyloid oligomers (PAOs) in atrial tissue has not been previously investigated.

Increasing evidence indicates that proteotoxicity plays a pathophysiologic role in experimental and human cardiomyopathy. In organ-specific amyloidoses, soluble protein oligomers are the primary cytotoxic species in the process of protein aggregation. While isolated atrial amyloidosis can develop with aging, the presence of preamyloid oligomers (PAOs) in atrial tissue has not been previously investigated.

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