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Master of Public Health

Adjuvant Therapy in Pancreas Cancer: Does It Influence Patterns of Recurrence?

AUTHORS

Parikh AA , Maiga A , Bentrem D , Squires MH , Kooby DA , Maithel SK , Weber SM , Cho CS , Katz M , Martin RC , Scoggins CR , Sutton J , Ahmad SA , Abbott DE , Carr J , Kim HJ , Yakoub D , Idrees K , Merchant N , . Journal of the American College of Surgeons. 2016 2 13; ().

ABSTRACT

Level 1 data demonstrate that adjuvant chemotherapy (ACT) improves survival after surgical resection of pancreatic ductal adenocarcinoma (PDAC), (adjuvant gemcitabine, CONKO-001 study; adjuvant 5-FU, ESPAC3 study). The role of adjuvant chemoradiation therapy (ACRT) remains controversial. What is less clear is whether adjuvant therapy influences patterns of recurrence. The purpose of this study was to perform the first multicenter study analyzing patterns of recurrence after adjuvant therapy for PDAC.

Level 1 data demonstrate that adjuvant chemotherapy (ACT) improves survival after surgical resection of pancreatic ductal adenocarcinoma (PDAC), (adjuvant gemcitabine, CONKO-001 study; adjuvant 5-FU, ESPAC3 study). The role of adjuvant chemoradiation therapy (ACRT) remains controversial. What is less clear is whether adjuvant therapy influences patterns of recurrence. The purpose of this study was to perform the first multicenter study analyzing patterns of recurrence after adjuvant therapy for PDAC.

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