A novel resistance mutation in eccC5 of the ESX-5 secretion system confers ofloxacin resistance in Mycobacterium tuberculosis.
AUTHORS
Eilertson
B ,
Maruri
F ,
Blackman
A ,
Guo
Y ,
Herrera
M ,
van der Heijden
Y ,
Shyr
Y ,
Sterling
TR ,
. The Journal of antimicrobial chemotherapy. 2016 9 ; 71(9). 2419-27
- PMID: PMC4992850 [PubMed].
- PMCID: PMC4992850.
- NIHMSID: 7513617
ABSTRACT
Fluoroquinolone resistance in Mycobacterium tuberculosis is often conferred by DNA gyrase mutations. However, a substantial proportion of fluoroquinolone-resistant M. tuberculosis isolates do not have such mutations.
Fluoroquinolone resistance in Mycobacterium tuberculosis is often conferred by DNA gyrase mutations. However, a substantial proportion of fluoroquinolone-resistant M. tuberculosis isolates do not have such mutations.
Tags: Faculty Publications 2016