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Master of Public Health

Accuracy of low-density lipoprotein cholesterol estimation at very low levels.

AUTHORS

Quispe R , Hendrani A , Elshazly MB , Michos ED , McEvoy JW , Blaha MJ , Banach M , Kulkarni KR , Toth PP , Coresh J , Blumenthal RS , Jones SR , Martin SS , . BMC medicine. 2017 4 20; 15(1). 83

ABSTRACT

As the approach to low-density lipoprotein cholesterol (LDL-C) lowering becomes increasingly intensive, accurate assessment of LDL-C at very low levels warrants closer attention in individualized clinical efficacy and safety evaluation. We aimed to assess the accuracy of LDL-C estimation at very low levels by the Friedewald equation, the de facto clinical standard, and compare its accuracy with a novel, big data-derived LDL-C estimate.

As the approach to low-density lipoprotein cholesterol (LDL-C) lowering becomes increasingly intensive, accurate assessment of LDL-C at very low levels warrants closer attention in individualized clinical efficacy and safety evaluation. We aimed to assess the accuracy of LDL-C estimation at very low levels by the Friedewald equation, the de facto clinical standard, and compare its accuracy with a novel, big data-derived LDL-C estimate.

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