Master of Public Health

Approaches for Optimizing Venous Thromboembolism (VTE) Prevention in Injured Patients: Findings from the Consensus Conference to Implement Optimal VTE Prophylaxis in Trauma

AUTHORS

ABSTRACT

Venous thromboembolism (VTE) is a major issue in trauma patients. Without prophylaxis, the rate of deep venous thrombosis approaches 60%, and even with chemoprophylaxis may be nearly 30%. Advances in VTE reduction are imperative to reduce the burden of this issue in the trauma population. Novel approaches in VTE prevention may include new medications, dosing regimens, and extending prophylaxis to the post-discharge phase of care. Standard dosing regimens of low molecular weight heparin (LMWH) are insufficient in trauma, shifting our focus towards alternative dosing strategies to improve prophylaxis. Mixed data suggest that anti-Xa guided dosage, weight-based dosing, and thromboelastography are among these potential strategies. The concern for VTE in trauma does not end upon discharge, however. The risk for venous thromboembolism in this population extends well beyond hospitalization. Variable extended thromboprophylaxis regimens utilizing aspirin, LMWH, and direct oral anticoagulants have been suggested to mitigate this prolonged VTE risk, but the ideal approach for outpatient VTE prevention is still unclear. As part of The 2022 Consensus Conference to Implement Optimal Venous Thromboembolism Prophylaxis in Trauma, a multidisciplinary array of participants, including physicians from multiple specialties, pharmacists, nurses, advanced practice providers, and patients met to attack these issues. This paper aims to review the current literature on novel approaches for optimizing VTE prevention in injured patients and identify research gaps which should be investigated to improve VTE rates in trauma.

Tags: alumni publications 2022