Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment.
AUTHORS
Vilgelm
AE ,
Johnson
CA ,
Prasad
N ,
Yang
J ,
Chen
SC ,
Ayers
GD ,
Pawlikowski
JS ,
Raman
D ,
Sosman
JA ,
Kelley
M ,
Ecsedy
JA ,
Shyr
Y ,
Levy
SE ,
Richmond
A ,
. Journal of the National Cancer Institute. 2016 6 ; 108(6).
- NIHMSID: 7503089
ABSTRACT
Tumor cell senescence is a common outcome of anticancer therapy. Here we investigated how therapy-induced senescence (TIS) affects tumor-infiltrating leukocytes (TILs) and the efficacy of immunotherapy in melanoma.
Tumor cell senescence is a common outcome of anticancer therapy. Here we investigated how therapy-induced senescence (TIS) affects tumor-infiltrating leukocytes (TILs) and the efficacy of immunotherapy in melanoma.
Tags: Faculty Publications 2016