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Master of Public Health

Coronary Artery Calcification and Rheumatoid Arthritis: Lack of Relationship to Risk Alleles for Coronary Artery Disease in the General Population.

AUTHORS

Ferraz-Amaro I , Winchester R , Gregersen PK , Reynolds RJ , Wasko MC , Oeser A , Chung CP , Stein CM , Giles JT , Bathon JM , . Arthritis & rheumatology (Hoboken, N.J.). 2016 10 1; ().

ABSTRACT

Coronary artery disease (CAD) in the general population is characterized by an increased frequency of particular susceptibility single nucleotide polymorphisms (SNPs). Since CAD is increased in rheumatoid arthritis (RA), we sought to determine whether the frequency of these SNPs are increased in RA patients with CAD, hypothesizing that RA could enhance CAD risk by acting through established genetic pathways predisposing to CAD.

Coronary artery disease (CAD) in the general population is characterized by an increased frequency of particular susceptibility single nucleotide polymorphisms (SNPs). Since CAD is increased in rheumatoid arthritis (RA), we sought to determine whether the frequency of these SNPs are increased in RA patients with CAD, hypothesizing that RA could enhance CAD risk by acting through established genetic pathways predisposing to CAD.

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