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Master of Public Health

Coronary Artery Calcium and Risk of Dementia in MESA (Multi-Ethnic Study of Atherosclerosis).

AUTHORS

Fujiyoshi A , Jacobs DR , Fitzpatrick AL , Alonso A , Duprez DA , Sharrett AR , Seeman T , Blaha MJ , Luchsinger JA , Rapp SR , . Circulation. Cardiovascular imaging. 2017 5 1; 10(5).

ABSTRACT

Studies suggest a link between vascular injuries and dementia. Only a few studies, however, examined a longitudinal relation of subclinical vascular disease with dementia. We tested whether baseline coronary artery calcium (CAC), a biomarker of subclinical vascular disease, is associated with incident dementia independent of vascular risk factors and APOE-ε4 genotype in a community-based sample.

Studies suggest a link between vascular injuries and dementia. Only a few studies, however, examined a longitudinal relation of subclinical vascular disease with dementia. We tested whether baseline coronary artery calcium (CAC), a biomarker of subclinical vascular disease, is associated with incident dementia independent of vascular risk factors and APOE-ε4 genotype in a community-based sample.

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