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Master of Public Health

Diagnostic Performance of Magnetic Resonance Imaging for Pediatric Ovarian Neoplasms: A Multi-Institutional Review

AUTHORS

Bergus KC , Knaus ME , Onwuka AJ , Afrazi A , Breech L , Corkum KS , Dillon PA , Ehrlich PF , Fallat ME , Fraser JD , Gadepalli SK , Grabowski JE , Hertweck SP , Kabre R , Lal DR , Landman MP , Leys CM , Mak GZ , Markel TA , Merchant N , Overman RE , Rademacher BL , Raiji MT , Rymeski B , Sato TT , Wright T , Aldrink JH , Hewitt GD , Minneci PC , Deans KJ , , . Journal of pediatric and adolescent gynecology. 2023 11 24; ().

ABSTRACT

STUDY OBJECTIVE: To assess diagnostic performance of MRI to predict ovarian malignancy alone and compared to other diagnostic studies.

METHODS: Retrospective analysis of patients aged 2 to 21 years who underwent ovarian mass resection between 2009-2021 at eleven pediatric hospitals. Sociodemographic information, clinical and imaging findings, tumor markers, and operative and pathology details were collected. Diagnostic performance for detecting malignancy was assessed by calculating sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for MRI with other diagnostic modalities.

RESULTS: 1,053 patients underwent resection of an ovarian mass with a median age of 14.6 years; 10% (110/1053) had malignant disease on pathology and 13% (136/1053) underwent preoperative MRI. MRI sensitivity, specificity, PPV, and NPV were 60%, 94%, 60%, 94%. Ultrasound sensitivity, specificity, PPV, and NPV were 31%, 99%, 73%, 95%. Tumor marker sensitivity, specificity, PPV, and NPV were 90%, 46%, 22%, 96%. MRI and ultrasound concordance was 88% with sensitivity, specificity, PPV, and NPV of 33%, 99%, 75%, 94%. MRI sensitivity in ultrasound-discordant cases was 100%. MRI and tumor marker concordance was 88% with sensitivity, specificity, PPV, and NPV of 100%, 86%, 64%, 100%. MRI specificity in tumor marker-discordant cases was 100%.

CONCLUSION: Diagnostic modalities used to assess ovarian neoplasms in pediatric patients typically agree. In cases of disagreement, MRI is more sensitive for malignancy than ultrasound and more specific than tumor markers. Selective use of MRI with preoperative ultrasound and tumor markers may be beneficial when the risk of malignancy is uncertain.

CONCISE ABSTRACT: This retrospective review of 1053 patients age 2-21 years who underwent ovarian mass resection between 2009-2021 at 11 pediatric hospitals found that ultrasound, tumor markers, and MRI tend to agree on benign vs malignant but in cases of disagreement, MRI is more sensitive for malignancy than US.

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