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Master of Public Health

Epidemiologic Association Between FUT2 Secretor Status and Severe Rotavirus Gastroenteritis in Children in the United States.

AUTHORS

Payne DC , Currier RL , Staat MA , Sahni LC , Selvarangan R , Halasa NB , Englund JA , Weinberg GA , Boom JA , Szilagyi PG , Klein EJ , Chappell J , Harrison CJ , Davidson BS , Mijatovic-Rustempasic S , Moffatt MD , McNeal M , Wikswo M , Bowen MD , Morrow AL , Parashar UD , . JAMA pediatrics. 2015 9 21; (). 1-6

ABSTRACT

A genetic polymorphism affecting FUT2 secretor status in approximately one-quarter of humans of European descent affects the expression of histo-blood group antigens on the mucosal epithelia of human respiratory, genitourinary, and digestive tracts. These histo-blood group antigens serve as host receptor sites necessary for attachment and infection of some pathogens, including norovirus.

A genetic polymorphism affecting FUT2 secretor status in approximately one-quarter of humans of European descent affects the expression of histo-blood group antigens on the mucosal epithelia of human respiratory, genitourinary, and digestive tracts. These histo-blood group antigens serve as host receptor sites necessary for attachment and infection of some pathogens, including norovirus.

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