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Master of Public Health

In-Hospital Pneumococcal Polysaccharide Vaccination Is Associated With Detection of Pneumococcal Vaccine Serotypes in Adults Hospitalized for Community-Acquired Pneumonia.

AUTHORS

Grijalva CG , Wunderink RG , Zhu Y , Williams DJ , Balk R , Fakhran S , Courtney DM , Anderson EJ , Qi C , Trabue C , Pavia AT , Moore MR , Jain S , Edwards KM , Self WH , . Open forum infectious diseases. 2015 12 ; 2(4). ofv135

ABSTRACT

During an etiology study of adults hospitalized for pneumonia, in which urine specimens were examined for serotype-specific pneumococcal antigen detection, we observed that some patients received 23-valent pneumococcal polysaccharide vaccine before urine collection. Some urine samples became positive for specific vaccine pneumococcal serotypes shortly after vaccination, suggesting false-positive test results.

During an etiology study of adults hospitalized for pneumonia, in which urine specimens were examined for serotype-specific pneumococcal antigen detection, we observed that some patients received 23-valent pneumococcal polysaccharide vaccine before urine collection. Some urine samples became positive for specific vaccine pneumococcal serotypes shortly after vaccination, suggesting false-positive test results.

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