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Master of Public Health

Innate susceptibility to norovirus infections influenced by FUT2 genotype in a United States pediatric population.

AUTHORS

Currier RL , Payne DC , Staat MA , Selvarangan R , Shirley SH , Halasa N , Boom JA , Englund JA , Szilagyi PG , Harrison CJ , Klein EJ , Weinberg GA , Wikswo ME , Parashar U , Vinjé J , Morrow AL , . Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2015 3 5; ().

ABSTRACT

 Norovirus is a leading cause of acute gastroenteritis (AGE). Noroviruses bind to gut histo-blood group antigens (HBGAs), but only 70-80% of individuals have a functional copy of the FUT2 (“secretor”) gene required for gut HBGA expression; these individuals are known as “secretors.” Susceptibility to some noroviruses depends on FUT2 secretor status, but the population impact of this association is not established.

 Norovirus is a leading cause of acute gastroenteritis (AGE). Noroviruses bind to gut histo-blood group antigens (HBGAs), but only 70-80% of individuals have a functional copy of the FUT2 (“secretor”) gene required for gut HBGA expression; these individuals are known as “secretors.” Susceptibility to some noroviruses depends on FUT2 secretor status, but the population impact of this association is not established.

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