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Master of Public Health

Making thawed universal donor plasma available rapidly for massively bleeding trauma patients: experience from the Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial.

AUTHORS

Novak DJ , Bai Y , Cooke RK , Marques MB , Fontaine MJ , Gottschall JL , Carey PM , Scanlan RM , Fiebig EW , Shulman IA , Nelson JM , Flax S , Duncan V , Daniel-Johnson JA , Callum JL , Holcomb JB , Fox EE , Baraniuk S , Tilley BC , Schreiber MA , Inaba K , Rizoli S , Podbielski JM , Cotton BA , Hess JR , , . Transfusion. 2015 3 30; ().

ABSTRACT

The Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial was a randomized clinical trial comparing survival after transfusion of two different blood component ratios for emergency resuscitation of traumatic massive hemorrhage. Transfusion services supporting the study were expected to provide thawed plasma, platelets, and red blood cells within 10 minutes of request.

The Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial was a randomized clinical trial comparing survival after transfusion of two different blood component ratios for emergency resuscitation of traumatic massive hemorrhage. Transfusion services supporting the study were expected to provide thawed plasma, platelets, and red blood cells within 10 minutes of request.

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