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Master of Public Health

Mitochondrial DNA Haplogroups and Neurocognitive Impairment during HIV Infection.

AUTHORS

Hulgan T , Samuels DC , Bush W , Ellis RJ , Letendre SL , Heaton RK , Franklin DR , Straub P , Murdock DG , Clifford DB , Collier AC , Gelman BB , Marra CM , McArthur JC , McCutchan JA , Morgello S , Simpson DM , Grant I , Kallianpur AR , , . Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2015 6 30; ().

ABSTRACT

 Neurocognitive impairment (NCI) remains an important complication in HIV-infected persons. Ancestry-related Mitochondrial DNA (mtDNA) haplogroups have been associated with outcomes of HIV infection and combination antiretroviral therapy (CART), and with neurodegenerative diseases. We hypothesize that mtDNA haplogroups are associated with NCI in HIV-infected adults, and performed a genetic association study in the CHARTER cohort.

 Neurocognitive impairment (NCI) remains an important complication in HIV-infected persons. Ancestry-related Mitochondrial DNA (mtDNA) haplogroups have been associated with outcomes of HIV infection and combination antiretroviral therapy (CART), and with neurodegenerative diseases. We hypothesize that mtDNA haplogroups are associated with NCI in HIV-infected adults, and performed a genetic association study in the CHARTER cohort.

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