Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons

AUTHORS

Young JE , Jayadev S , . Cell stem cell. ; 29(8). 1159-1160

PMID: 35931027 [PubMed].

ABSTRACT

In this issue of Cell Stem Cell, Victor et al. reveal that human microglia harboring the Alzheimer’s disease risk allele APOE4 have altered lipid metabolism and cellular activation. This dampens neuronal network activity, underscoring the importance of these brain-resident immune cells and highlighting a novel pathway for therapeutic intervention.

Tags: alumni publications 2022