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Master of Public Health

Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm.

AUTHORS

Owens AP , Edwards TL , Antoniak S , Geddings JE , Jahangir E , Wei WQ , Denny JC , Boulaftali Y , Bergmeier W , Daugherty A , Sampson UK , Mackman N , . Arteriosclerosis, thrombosis, and vascular biology. 2015 7 2; ().

ABSTRACT

Rupture of abdominal aortic aneurysms causes a high morbidity and mortality in the elderly population. Platelet-rich thrombi form on the surface of aneurysms and may contribute to disease progression. In this study, we used a pharmacological approach to examine a role of platelets in established aneurysms induced by angiotensin II infusion into hypercholesterolemic mice.

Rupture of abdominal aortic aneurysms causes a high morbidity and mortality in the elderly population. Platelet-rich thrombi form on the surface of aneurysms and may contribute to disease progression. In this study, we used a pharmacological approach to examine a role of platelets in established aneurysms induced by angiotensin II infusion into hypercholesterolemic mice.

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