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Master of Public Health

Risk of death and readmission among individuals with heart failure and HIV: A systematic review and meta-analysis

AUTHORS

Zhou Y , Zhang X , Gao Y , Alvi RM , Erqou S , Chen Y , Wang H , Wang W , Li X , Zanni MV , Neilan TG , Vermund SH , Qian HZ , Qian F , . Journal of infection and public health. 2023 11 7; 17(1). 70-75

ABSTRACT

The association between human immunodeficiency virus (HIV) status and readmissions and death outcomes in patients with established heart failure (HF) remains unclear. We conducted a systematic search of PubMed, EMBASE, Cochrane Library, and Web of Science up to March 1st, 2023, for cohort studies of adult patients (≥18 years) diagnosed with HF and recorded HIV status at baseline. Our analysis included 7 studies with 10,328 HF patients living with HIV and 48,757 HF patients without HIV. Compared to HF patients without HIV, those with HIV had a higher risk of all-cause deaths (HR: 1.20, 95% CI: 1.15-1.25). HIV infection was also associated with increased risks of HF-associated readmission (HR: 1.34, 95% CI: 1.03-1.75) and all-cause readmission (HR: 1.27, 95% CI: 1.10-1.46). Our study highlights the independent association between HIV and poor HF outcomes, emphasizing the need for improved management in individuals living with HIV.

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