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Master of Public Health

Rotavirus vaccine effectiveness in low-income settings: An evaluation of the test-negative design.

AUTHORS

Schwartz LM , Halloran ME , Rowhani-Rahbar A , Neuzil KM , Victor JC , . Vaccine. 2016 11 18; ().

ABSTRACT

The test-negative design (TND), an epidemiologic method currently used to measure rotavirus vaccine (RV) effectiveness, compares the vaccination status of rotavirus-positive cases and rotavirus-negative controls meeting a pre-defined case definition for acute gastroenteritis. Despite the use of this study design in low-income settings, the TND has not been evaluated to measure rotavirus vaccine effectiveness.

The test-negative design (TND), an epidemiologic method currently used to measure rotavirus vaccine (RV) effectiveness, compares the vaccination status of rotavirus-positive cases and rotavirus-negative controls meeting a pre-defined case definition for acute gastroenteritis. Despite the use of this study design in low-income settings, the TND has not been evaluated to measure rotavirus vaccine effectiveness.

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