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Master of Public Health

Safety and Immunogenicity of a Single Low or High Dose of Clade 2 H5N1 Inactivated Influenza Vaccine in Adults Previously Primed with Clade 1 H5N1 Vaccine.

AUTHORS

Winokur PL , Patel SM , Brady R , Chen WH , El-Kamary SS , Edwards K , Creech CB , Frey S , Keitel WA , Belshe R , Walter E , Bellamy A , Hill H , . The Journal of infectious diseases. 2015 2 23; ().

ABSTRACT

H5N1 influenza vaccination strategies that improve the immunological speed and cross-clade protection are desired. We compared the immunogenicity of a single 15 or 90 mcg dose of A/H5N1/Indonesia/05/05 (Clade 2) vaccine in adults who were previously primed with A/H5N1/Vietnam/1203/2004 (Clade 1) vaccine. High dose vaccine resulted in significantly higher titers to both clade 1 and 2 antigens. Clade 2 titers were unaffected by the previous dose of clade 1 vaccine. Low dose priming with a mismatched pandemic H5N1 vaccine would improve the rapidity, magnitude and cross reactivity of the immunological response following a single high dose, unadjuvanted, pandemic vaccine.

H5N1 influenza vaccination strategies that improve the immunological speed and cross-clade protection are desired. We compared the immunogenicity of a single 15 or 90 mcg dose of A/H5N1/Indonesia/05/05 (Clade 2) vaccine in adults who were previously primed with A/H5N1/Vietnam/1203/2004 (Clade 1) vaccine. High dose vaccine resulted in significantly higher titers to both clade 1 and 2 antigens. Clade 2 titers were unaffected by the previous dose of clade 1 vaccine. Low dose priming with a mismatched pandemic H5N1 vaccine would improve the rapidity, magnitude and cross reactivity of the immunological response following a single high dose, unadjuvanted, pandemic vaccine.

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