Serological Response to Influenza Vaccination Among Adults Hospitalized with Community Acquired Pneumonia

AUTHORS

Pratt CQ , Zhu Y , Grijalva CG , Wunderink RG , Courtney DM , Waterer G , Levine MZ , Jefferson S , Self WH , Williams DJ , Finelli L , Bramley AM , Edwards KM , Jain S , Anderson EJ , . Influenza and other respiratory viruses. 2018 11 28; ().

PMID: 30485702 [PubMed].

ABSTRACT

Ninety-five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology were performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty-six (69%) patients seroconverted (≥4-fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season. This article is protected by copyright. All rights reserved.

Tags: Alumni Publications 2018, Faculty Publications 2018