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Master of Public Health

Splenectomy is associated with hypercoagulable thrombelastography values and increased risk of thromboembolism.

AUTHORS

Pommerening MJ , Rahbar E , Minei K , Holcomb JB , Wade CE , Schreiber MA , Cohen MJ , Underwood SJ , Nelson M , Cotton BA , . Surgery. 2015 7 21; ().

ABSTRACT

Previous investigators have demonstrated that postinjury thrombocytosis is associated with an increase in thromboembolic (TE) risk. Increased rates of thrombocytosis have been found specifically in patients after splenectomy for trauma. We hypothesized that patients undergoing splenectomy (1) would demonstrate a more hypercoagulable profile during their hospital stay and (2) that this hypercoagulable state would be associated with increased TE events.

Previous investigators have demonstrated that postinjury thrombocytosis is associated with an increase in thromboembolic (TE) risk. Increased rates of thrombocytosis have been found specifically in patients after splenectomy for trauma. We hypothesized that patients undergoing splenectomy (1) would demonstrate a more hypercoagulable profile during their hospital stay and (2) that this hypercoagulable state would be associated with increased TE events.

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