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Master of Public Health

The impact of tranexamic acid on mortality in injured patients with hyperfibrinolysis.

AUTHORS

Harvin JA , Peirce CA , Mims MM , Hudson JA , Podbielski JM , Wade CE , Holcomb JB , Cotton BA , . The journal of trauma and acute care surgery. 2015 5 1; 78(5). 905-11

ABSTRACT

In 2011, supported by data from two separate trauma centers, we implemented a protocol to administer tranexamic acid (TXA) in trauma patients with evidence of hyperfibrinolysis (HF) on admission. The purpose of this study was to examine whether the use of TXA in patients with HF determined by admission rapid thrombelastography was associated with improved survival.

In 2011, supported by data from two separate trauma centers, we implemented a protocol to administer tranexamic acid (TXA) in trauma patients with evidence of hyperfibrinolysis (HF) on admission. The purpose of this study was to examine whether the use of TXA in patients with HF determined by admission rapid thrombelastography was associated with improved survival.

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