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Master of Public Health

Timing of Antiretroviral Treatment, Immunovirologic Status and TB Risk: Implications for Test and Treat.

AUTHORS

Pettit AC , Mendes A , Jenkins C , Napravnik S , Freeman A , Shepherd BE , Dowdy D , Gill J , Rachlis A , Moore R , Sterling TR , , . Journal of acquired immune deficiency syndromes (1999). 2016 4 5; ().

ABSTRACT

TB risk and mortality increase in the six months following HAART initiation. This short-term risk may be a consequence of HAART initiation and immune reconstitution. Alternatively, it may be due to confounding by low CD4+ counts and high HIV viral loads (VL). We assessed TB risk before and after HAART initiation while appropriately controlling for time-updated laboratory values and HAART exposure.

TB risk and mortality increase in the six months following HAART initiation. This short-term risk may be a consequence of HAART initiation and immune reconstitution. Alternatively, it may be due to confounding by low CD4+ counts and high HIV viral loads (VL). We assessed TB risk before and after HAART initiation while appropriately controlling for time-updated laboratory values and HAART exposure.

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