Use of Interferon Gamma Release Assays in Children <2 Years Old

AUTHORS

Turner NA , Ahmed A , Haley CA , Starke JR , Stout JE , . Journal of the Pediatric Infectious Diseases Society. 2023 7 21; ().

PMID: 37478309 [PubMed].

ABSTRACT

While interferon gamma release assays (IGRA) are widely used for detecting tuberculosis infection, tuberculin skin tests (TST) remain preferred for children under the age of 2 years. The preference for TST stems from concern over IGRA sensitivity in young children. However, TSTs are susceptible to false positive results following Bacille Calmette-Guérin (BCG) vaccination which is common in infancy, and exposure to nontuberculous mycobacteria. We reviewed available data for IGRA performance in children under age 2 years. Across four cohorts of high-risk children under age 2 (mostly case contacts or those born in tuberculosis endemic regions), 0 of 575 untreated children with negative IGRA test results progressed to tuberculosis disease – including 0 of 70 who were TST positive but IGRA negative. While neither TST nor IGRA are perfectly sensitive for diagnosis of tuberculosis infection, IGRAs are an acceptable alternative to TST in children <2 years of age.

Tags: 2023 Alumni Publications