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Master of Public Health

Utility of [(18)F]FSPG PET to Image Hepatocellular Carcinoma: First Clinical Evaluation in a US Population.

AUTHORS

Kavanaugh G , Williams J , Morris AS , Nickels ML , Walker R , Koglin N , Stephens AW , Washington MK , Geevarghese SK , Liu Q , Ayers D , Shyr Y , Manning HC , . Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2016 9 27; ().
  • NIHMSID: 101125610

ABSTRACT

Non-invasive imaging is central to hepatocellular carcinoma (HCC) diagnosis; however, conventional modalities are limited by smaller tumors and other chronic diseases that are often present in patients with HCC, such as cirrhosis. This pilot study evaluated the feasibility of (4S)-4-(3-[(18)F]fluoropropyl)-L-glutamic acid ([(18)F]FSPG) positron emission tomography (PET)/X-ray computed tomography (CT) to image HCC. [(18)F]FSPG PET/CT was compared to standard-of-care (SOC) magnetic resonance imaging (MRI) and CT, and [(11)C]acetate PET/CT, commonly used in this setting. We report the largest cohort of HCC patients imaged to date with [(18)F]FSPG PET/CT and present the first comparison to [(11)C]acetate PET/CT and SOC imaging. This study represents the first in a US HCC population, which is distinguished by different underlying comorbidities than non-US populations.

Non-invasive imaging is central to hepatocellular carcinoma (HCC) diagnosis; however, conventional modalities are limited by smaller tumors and other chronic diseases that are often present in patients with HCC, such as cirrhosis. This pilot study evaluated the feasibility of (4S)-4-(3-[(18)F]fluoropropyl)-L-glutamic acid ([(18)F]FSPG) positron emission tomography (PET)/X-ray computed tomography (CT) to image HCC. [(18)F]FSPG PET/CT was compared to standard-of-care (SOC) magnetic resonance imaging (MRI) and CT, and [(11)C]acetate PET/CT, commonly used in this setting. We report the largest cohort of HCC patients imaged to date with [(18)F]FSPG PET/CT and present the first comparison to [(11)C]acetate PET/CT and SOC imaging. This study represents the first in a US HCC population, which is distinguished by different underlying comorbidities than non-US populations.

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