Compounds
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1. TEV Biotin Probe
10 Step Synthesis
Nature Protocols 2007, 2, 1414
2. Bacillithiol, Isolated from Gram Positive Bacteria
8 Step Synthesis
Sulikowski et al, Org Lett. 2012, 14, 5207
3. DADPS Biotin Probe
4 Step Synthesis
JACS 2010, 132, 18351
4. LDN 193189
5 Step Synthesis
Bioorg. Med. Chem. 2008, 18, 4388
5. L-000734635
15 Step Synthesis
US Patent 5,952,321 (Merck & Co)
6. VUAA1 Insect Repellent
2 Step Synthesis
Proc. Natl. Acad. Sci. USA 2011, 108, 8821
7. VNI CYP51 Inhibitor
9 Step Synthesis
Int. J. Parasitol. Drugs Drug Resist. 2012, 2, 178
8. Omega-Hydroxyceramide
9 Step Synthesis
Liebigs Ann. Chem. 1991, 529
9. Acid-Sensitive Ion Channel Inhibitor (IC50 356nm)
8 Step Synthesis
ACS Chem. Neurosci. 2010, 1, 19
10. M1 Allosteric Modulator VU040562 (EC50 1.3 nM)
HTS Follow-Up: Analysis, Hit Triage, Cherry-Pick & Med Chem
Lindsley et al., Bioorg. Med. Chem. Lett. 2011, 21, 2697
11. BMS-345541
7 Step Synthesis
J. Biol. Chem. 2003, 278, 1450
12. Ammocidin A; from Saccharothrix sp. AJ9571
F1 ATP synthase inhibitor, suitable for in vivo use
Reisman, Sulikowski, Bachmann, et. al.
Nature Chemical Biology doi: 10.1038/s41589-021-00900-9
13. Apoptolidin A; from Nocardiopsis sp. FU40
F1 ATP synthase inhibitor
DeGuire, Bachmann, Sulikowski, et al.,
Angew. Chem. Ed. 2015, 54, 961
