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Enabled Publications

The chemical synthesis core has enabled a variety of chemical biology, pre-clinical and other studies by providing either commercially unavailable or available compounds at a significantly reduced expense. Examples of resulting publications are provided for illustrative purposes.


ChangSC, Fedeles BI, Wu J, Delaney JC, Li D, Zhao L, Christov PP, Yau E, Singh V, Jost M, Drennan CL, Marnett LJ, Rizzo CJ, Levine SS, Guengerich FP, Essigmann JM, Next-generation sequencing reveals the biological significance of the N2,3-ethenoguanine lesion in v…Nucleic acids research. 2015 Apr 2
LepeshevaGI, Hargrove TY, Rachakonda G, Wawrzak Z, Pomel S, Cojean S, Nde PN, Nes WD, Locuson CW, Calcutt MW, Waterman MR, Daniels JS, Loiseau PM, Villalta F, VFV as a new effective CYP51 structure-derived drug candidate for Chagas disease and visceral leishm…The Journal of infectious diseases. 2015 Apr 15


PetersenCP, Weis VG, Nam KT, Sousa JF, Fingleton B, Goldenring JR, Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of…Gastroenterology. 2014 Jun 146 (7). 1727-38.e8
DadiPK, Vierra NC, Jacobson DA, Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry an…Endocrinology. 2014 Oct 155 (10). 3757-68


CouchFB, Bansbach CE, Driscoll R, Luzwick JW, Glick GG, Bétous R, Carroll CM, Jung SY, Qin J, Cimprich KA, Cortez D, ATR phosphorylates SMARCAL1 to prevent replication fork collapse.Genes & development. 2013 Jul 15 27 (14). 1610-23
SirbuBM, McDonald WH, Dungrawala H, Badu-Nkansah A, Kavanaugh GM, Chen Y, Tabb DL, Cortez D, Identification of proteins at active, stalled, and collapsed replication forks using isolation of pr…The Journal of biological chemistry. 2013 Nov 1 288 (44). 31458-67
LamorteL, Titolo S, Lemke CT, Goudreau N, Mercier JF, Wardrop E, Shah VB, von Schwedler UK, Langelier C, Banik SS, Aiken C, Sundquist WI, Mason SW, Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes.Antimicrobial agents and chemotherapy. 2013 Oct 57 (10). 4622-31


SirbuBM, Couch FB, Feigerle JT, Bhaskara S, Hiebert SW, Cortez D, Analysis of protein dynamics at active, stalled, and collapsed replication forks.Genes & development. 2011 Jun 15 25 (12). 1320-7


BlairWS, Pickford C, Irving SL, Brown DG, Anderson M, Bazin R, Cao J, Ciaramella G, Isaacson J, Jackson L, Hunt R, Kjerrstrom A, Nieman JA, Patick AK, Perros M, Scott AD, Whitby K, Wu H, Butler SL, HIV capsid is a tractable target for small molecule therapeutic intervention.PLoS pathogens. 2010 6 (12). e1001220