Compounds

 

Compounds

  1 TEV Biotin Probe
  2 Bacillithiol, Isolated from Gram Positive Bacteria
  3 DADPS Biotin Probe
  4 LDN 193189
  5 L-000734635
  6 VUAA1 Insect Repellent
  7 VNI  CYP51 Inhibitor 
  8 Omega-Hydroxyceramide
  9 Acid-Sensitive Ion Channel Inhibitor (IC50 356nm)
10 M1 Allosteric Modulator VU040562 (EC50 1.3 nM)
11 BMS-345541

 

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1.  TEV Biotin Probe

           10 Step Synthesis
           Nature Protocols 2007, 2, 1414

syncore_TEV_Biotin_Probe_nopricing.jpg
 

2.  Bacillithiol, Isolated from Gram Positive Bacteria

           8 Step Synthesis
​           Sulikowski et al, Org Lett. 2012, 14, 5207

syncore_Bacillithiol_nopricing.jpg

 

3.  DADPS Biotin Probe

          4 Step Synthesis
          JACS 2010, 132, 18351

syncore_DADPS-Biotin-Probe_nopricing.jpg

 

4.  LDN 193189

           5 Step Synthesis
           Bioorg. Med. Chem. 2008, 18, 4388

syncore_LDN-193189_nopricing.jpg

 

5.  L-000734635

          15 Step Synthesis
          US Patent 5,952,321 (Merck & Co)

syncore_L-000734635_nopricing.jpg

 

6.  VUAA1  Insect Repellent

           2 Step Synthesis
           Proc. Natl. Acad. Sci. USA 2011, 108, 8821

syncore_VUAA1_nopricing.jpg
 

 

7.  VNI CYP51 Inhibitor

           9 Step Synthesis
           Int. J. Parasitol. Drugs Drug Resist. 2012, 2, 178

syncore_VNI_nopricing.jpg

 

8.  Omega-Hydroxyceramide

           9 Step Synthesis
           Liebigs Ann. Chem. 1991, 529

syncore_Omega-hydroxyceramide_nopricing.jpg

 

9.  Acid-Sensitive Ion Channel Inhibitor (IC50 356nm)

          8 Step Synthesis
          
ACS Chem. Neurosci. 2010, 1, 19

syncore_Acid-sensitive_ion_inhibitor_nopricing.jpg

 

10.  M1 Allosteric Modulator VU040562 (EC50 1.3 nM)

              HTS Follow-Up: Analysis, Hit Triage, Cherry-Pick & Med Chem
              Lindsley et al., Bioorg. Med. Chem. Lett. 2011, 21, 2697

syncore_M1_Allosteric_Modulator_nopricing.jpg

 

11.  BMS-345541

              7 Step Synthesis
​              J. Biol. Chem. 2003, 278, 1450

syncore_BMS-345541_nopricing.jpg

 

 

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