Synthesis of tetranor-PGE: a urinary metabolite of prostaglandins E and E
AUTHORS
Kimbrough
JR ,
Jana
S ,
Kim
K ,
Allweil
A ,
Oates
JA ,
Milne
GL ,
Sulikowski
GA ,
. Tetrahedron letters. 2020 4 10; 61(22).
- PMID: 32523235 [PubMed].
ABSTRACT
Prostaglandin E is produced in response to inflammation, often associated with human disease. As prostaglandins are rapidly metabolized, quantification of end urinary metabolites depend on chemical synthesis of isotopically labeled standards to support metabolite quantification. A concise synthesis of tetranor-PGE is described including a late stage incorporation of an isotopically labeled side-chain.
Tags: 2020