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Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal E


AUTHORS

Boer RE , Giménez-Bastida JA , Boutaud O , Jana S , Schneider C , Sulikowski GA , . Organic letters. 2018 12 6; 20(13). 4020-4022

ABSTRACT

The total synthesis of hemiketal E (HKE) has been accomplished using a gold(I)-mediated cycloisomerization followed by oxidation of the enol ether product to introduce a unique keto-hemiketal, the core structure of HKE. Synthetic hemiketal E reproduced biosynthetically derived HKE in the inhibition of human platelet aggregation.



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