Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal E
AUTHORS
- PMID: 29916257 [PubMed].
ABSTRACT
The total synthesis of hemiketal E (HKE) has been accomplished using a gold(I)-mediated cycloisomerization followed by oxidation of the enol ether product to introduce a unique keto-hemiketal, the core structure of HKE. Synthetic hemiketal E reproduced biosynthetically derived HKE in the inhibition of human platelet aggregation.
Tags: 2018