The School of Medicine Basic Sciences consists of a remarkable community that is dedicated to advancing the study of human biology, health, and disease. In addition to the award-winning faculty, postdocs, and students who are at the forefront of our cutting-edge research, a large part of our school’s success can be attributed to our staff.
Join us in recognizing and appreciating our staff members and the hard work they do to ensure exceptional exploration into basic biomedical science that takes place at our school.
We sat down with Jo Ann Byl, senior research specialist in Department of Biochemistry, who told us a little about herself.
How long have you been working for Vanderbilt?
Thirty-one years! Currently and in addition to my research responsibilities, I assist graduate students, keep the lab of Neil Osheroff stocked with supplies, and upkeep our lab equipment.
What is unique about working for the School of Medicine Basic Sciences?
I am challenged with problem solving, whether it involves experimental procedures, research projects, or lab issues. Although I can be faced with frustration, I feel like my mind is being challenged.
What is an upcoming project that you are looking forward to?
Right now, I am working to determine the structural and functional effects of tetrahydroquinoline derivatives on human topoisomerase II.
What is your favorite memory or project you have completed during your time at the School of Medicine Basic Sciences so far?
My favorite project so far was the one that resulted in research that was published in the journal ACS Infectious Diseases in February 2023. Our team identified a new class of antibacterial drugs, spiropyrimidinetriones, with a strong potential to treat tuberculosis, including drug-resistant strains. These SPTs showed high activity against Mycobacterium tuberculosis, outperformed some existing fluoroquinolones, and demonstrated low off-target effects, supporting their development for combating resistant infections.
Who has had a positive impact on your work?
I feel that all past and current graduate students and postdocs have had a positive influence on me. One particular person who had a positive impact on me was Hunter Lindsey, who unfortunately died of cancer during his second tenure at Vanderbilt. He brought humor and camaraderie to the Osheroff lab.
What is an achievement that you are most proud of?
I am most proud of serving Saturday breakfast to the homeless at my church and heading up our annual Waffle Shop fundraiser event.
What is a fun fact about you?
I attended a karate class with Elvis when I was a teenager in Memphis. He was in the first American movie I saw in Korea when I was a child.
What activities to do you like to do outside of work?
Reading, knitting, and crocheting!
What is your favorite quote?
“Our prime purpose in this life is to help others. And if you can’t help them, at least don’t hurt them.” – Dalai Lama