Discoveries

  • 3D-rendered C. difficile bacteria. They are rods with bulges at one end. They are white/transparent and purple. The background is blurry and not discernible.

    Preventing CDI deaths one stem cell at a time

    https://cdn.vanderbilt.edu/vu-web/medschool-wpcontent/sites/64/2020/04/24143926/Lacy_Website.mp4   By Sara Eaton C. diff is responsible for 50% of gastrointestinal infections in hospitals but cause over 90% of GI tract infection-related deaths. © Kateryna_Kon, stock.adobe.com Gastrointestinal infections often cause damage to the stem cells in the colon’s epithelium, a thin layer of… Read More

    Apr. 23, 2020

  • An ounce of prevention is worth two pounds of cure

    An ounce of prevention is worth two pounds of cure

    https://cdn.vanderbilt.edu/vu-web/medschool-wpcontent/sites/64/2020/04/20165159/Goldenring_Website.mp4   By Sarah Glass Gastric cancer is one of the leading causes of cancer death in the U.S. © Crystal light, stock.adobe.com Clocking in at two pounds, the stomach is one of the body’s heaviest internal organs and can become afflicted with one of the leading causes of… Read More

    Apr. 10, 2020

  • A gloved hand holding a little resealable baggie with cocaine inside it. The glove is blue and the background is white.

    Lowering the dose of key medicine can reduce stress-induced relapse

    https://cdn.vanderbilt.edu/vu-web/medschool-wpcontent/sites/64/2020/04/05161825/Winder_website.mp4   By Sohini Roy Despite stringent regulation under the Controlled Substances Act, cocaine use disorder is widespread throughout the United States. © Bits and Splits, stock.adobe.com Cocaine is a highly addictive stimulant that is frequently abused in the United States despite stringent regulation under the Controlled Substances Act. Read More

    Apr. 3, 2020

  • Young person at an open fridge at night. They are eating a slice of pizza off a plate with another piece on it.

    Late-night meals may reduce how much fat your body burns at night

    https://cdn.vanderbilt.edu/vu-web/medschool-wpcontent/sites/64/2020/04/05161750/Johnson_website.mp4   By Heather Caslin Late-night snacks or meals affect how much fat we burn while we sleep, but the long-term effects on weight gain and health are not yet clear. © Pixel-Shot, stock.adobe.com Regulation of the body’s metabolism ensures that all organs receive the nutrients necessary for proper… Read More

    Apr. 3, 2020

  • Vanderbilt University

    Two is Better Than One: Combatting the Ebola Virus

    https://cdn.vanderbilt.edu/vu-web/medschool-wpcontent/sites/64/2020/03/01133722/Crowe_Website.mp4   By Sarah Glass Microscopic view of the Ebola virus. (jaddingt, stock.adobe.com) Many people associate Ebola with the previous viral epidemic of the last decade, but, especially in light of the current global SARS-CoV-2 pandemic, few are aware that there is currently an active outbreak occurring in the… Read More

    Mar. 26, 2020

  • Vanderbilt University

    Study explores link between cholesterol metabolism and environmental toxicants

    https://cdn.vanderbilt.edu/vu-web/medschool-wpcontent/sites/64/2020/03/23162530/Porter_Updated.mp4   By Stella Child In the last two decades, scientists have found increasing evidence for the contribution of environmental factors to neurodegenerative diseases. Organic solvents, heavy metals, and air pollutants are now all categorized as neurotoxicants, substances that affect the function of the nervous system. A subset of… Read More

    Mar. 23, 2020

  • Two segments of chromatin are shown. Each is made up of eight yellow balls (laid out in a four-by-two pattern) that represent histones and a colorful thread, representing DNA, that goes around the histones; collectively, these are the nucleosomes . The top chromatin has the nucleosomes more spread out than the bottom chromatin. Gene expression on the top chromatin is represented by a green protein that is shooting out segments of RNA. There is no gene expression on the bottom chromatin: the nucleosomes are tightly packed in a line and the DNA has a smattering of red spots throughout, representing methyl groups.

    ATAC-Me attacks knowledge gap in genetics research

    https://cdn.vanderbilt.edu/vu-web/medschool-wpcontent/sites/64/2020/03/18093522/Hodges.mp4   By Hillary Layden Most human cells contain roughly 6.5 feet of DNA, which must be tightly compacted to fit within the nucleus. Cells compact DNA by wrapping it around proteins called histones, forming a DNA-protein complex called chromatin. “Closed” chromatin is tightly compacted and cannot interact with… Read More

    Mar. 17, 2020

  • Vanderbilt University

    Pancreatic islet cells distinct in mice and humans

    By Cassandra Awgulewitsch https://cdn.vanderbilt.edu/vu-web/medschool-wpcontent/sites/64/2020/02/19153317/SteinDiabetes.mp4   Researchers in the lab of Roland Stein (Molecular Physiology & Biophysics), along with collaborators at UCSF, NC State, and UPenn, have shown distinct changes in human pancreatic islet cells throughout the course of life and the progression of type 2 diabetes. They also discovered… Read More

    Feb. 19, 2020

  • Vanderbilt University

    The tale of the targeted mouse

    By Sarah Glass https://cdn.vanderbilt.edu/vu-web/medschool-wpcontent/sites/64/2020/02/21182228/Coffey_Updated.mp4   3D illustration of colorectal cancer. Kateryna_Kon, stock.adobe.com. Researchers from the labs of Robert Coffey (Medicine) and Jacob Houghton (Radiology and Radiological Sciences) report in Gastroenterology the identification of two human antibodies, P1X and P2X, that can neutralize EGFR in mice. EGFR,… Read More

    Feb. 13, 2020

  • Vanderbilt University

    A master cellular conductor

    https://cdn.vanderbilt.edu/vu-web/medschool-wpcontent/sites/64/2020/02/24164531/Jackson_updated.2.mp4   This article was submitted by the senior author of the featured paper, Lauren P. Jackson. Cryo-EM image of retromer chain assembly. Courtesy of Amy K. Kendall Human cells contain a “FedEx system” to ensure that important protein and fatty lipid cargo molecules are delivered to the right… Read More

    Feb. 12, 2020