Council of Visitors

Subbu Apparsundaram, PhD

Subbu Apparsundaram, Ph.D., is an established scientist with extensive experience in drug
discovery and development. Dr. Subbu founded VClinBio that entered into strategic partnership
with Cellix Bio where he serves as CDO & COO. Previously, Subbu was a Drug Discovery
Scientist at Hoffmann-La Roche Pharmaceuticals, and a faculty at the University of Kentucky
Medical Center. He has published several peer reviewed research papers.

Brad Armstrong

Brad Armstrong is a successful entrepreneur and businessman, currently based in Texas. He is a family member of the late Dr. Richard Armstrong, a Vanderbilt faculty member whose groundbreaking work formed a basis for understanding the enzymatic function of antibiotic resistance. Together with members of the Armstrong family, Brad was a leader in the creation of the Armstrong Family Fund and The Richard N. Armstrong, Ph.D. Chair for Innovation in Biochemistry.

Laurent Audoly, PhD

Laurent Audoly, PhD, Laurent Audoly is a serial biotech entrepreneur and senior executive in the industry. Laurent has led and/or contributed to the identification and development of seven novel medicines (Xeljanz®, Hemangiol®, Javlor®, Renflexis®, Brenzys®, Ontruzant®, Hadlima® - biologics and small molecules) addressing unmet medical need across multiple disease areas that generate > $2B in annual sales. Laurent has also led business and R&D functions in both pharma and biotech (US and EU), developing and operationalizing strategies, modernizing pipelines and business models, bringing forward drug candidates into and through development, and partnering on multiple deals (buy and sell-sides, >$3B in total). He also serves as an independent board member in different organizations (Cytovia Therapeutics, Vanderbilt University). Laurent's latest biotech, Parthenon Therapeutics, operates at the intersection of systems biology, machine learning, molecular pharmacology, and drug development to find cures for recalcitrant cancers by reprogramming cellular pathways.Prior to founding Parthenon Therapeutics, Laurent was at the helm of Kymera Therapeutics as its founding CEO, President, and Director where he led the construction of the business, bringing in over $135M in funding and executing on > $1B in pharma partnership. Prior to this role, he was head of R&D with Fabre Pharmaceuticals (multinational pharma with $3B in top line), where he rebuilt the organization, led the in/out-licensing of multiple clinical stage assets and technologies, and directly contributed to IND entries, POC and LCM studies in oncology, dermatology, and CNS. Earlier in his career, Laurent held positions of increasing leadership responsibilities on the business and science fronts at Pfizer, Merck, MedImmune, and Pieris contributing to the advancement of 21 drug candidates into clinical development across multiple disease areas and modalities. He is also an inventor, has served on NIH study sections, and co-authored over 70 papers and patents. He studied chemistry (B.S. honors) and pharmacology (Ph.D.) at Vanderbilt University and was the recipient of an American Heart Association Fellowship at Duke University.

Robert Caldwell, PhD

Robert Caldwell, PhD, is a biomedical sciences expert with 18 years of medical research experience, spanning government contracting, academic medicine, and pharmaceutical collaboration. Rob is an expert advisor and published expert on all aspects regarding development of diagnostics to support medical care and biosurveillance, and advanced development and portfolio management, to include bioengineering efforts, industry best practices, strategic relations, and medical transition activities. He establishes and maintains relationships with relevant internal and external stakeholders in the biodefense community (i.e., combat and material developers, systems engineers, test and evaluation entities, industry, DOD, DHHS, DHS) and academic partners to evaluate current and emerging medical technologies and facilitate cross-communication regarding program priorities and courses of action. In addition, he assists in determining the strategic direction of the organization, participates in technology demonstrations and Science and Technology (S&T) transitions.

Andrea Carnegie, PhD

Andrea Carnegie, PhD, is the Chief Operating Officer of the North Carolina Translational and Clinical Sciences Institute. Prior to joining NC TRACS, she was the Director of Administrative Operations at the University of Illinois at the Chicago Center for Clinical and Translational Science. From 2007 to 2009, she was the administrative manager of the Oregon Retinal Degeneration Center at the Casey Eye Institute, Oregon Health & Science University in Portland, where she worked directly in clinical trial design and operations.Dr. Carnegie received a BS in Biology at Emory and a PhD in Pharmacology from Vanderbilt University as well as completing postdoctoral fellowships at Oregon Health & Science University. Her basic science work was on intracellular signaling mechanisms and biogenic amine transport in cardiac and neuronal cells. She is also an Assistant Professor of Medicine, in the Division of Endocrinology & Metabolism

Alexander "Zan" Fleming, MD

Alexander "Zan" Fleming, MD, is President and CEO of Tolerion, a biotechnology company developing disease-modifying treatments for type 1 diabetes and other autoimmune diseases. He is also Founder and Executive Chairman of Kinexum, a company of professionals from across the world with diverse expertise in developing drugs, biotech products, medical devices and digital health technologies. Dr. Fleming received his MD and internal medicine training from Emory University, fellowship training in endocrinology at Vanderbilt University and metabolism at National Institutes of Health, where he was a senior fellow.At the US Food and Drug Administration (FDA) from 1986-98, Dr. Fleming was responsible for the therapeutic areas of diabetes, other metabolic and endocrine disorders, growth and development, nutrition, lipid-lowering compounds, and reproductive indications. He led reviews of landmark approvals including metformin and the first statin, insulin analog, PPAR-agonist, and growth hormone for non-GH deficiency indications. Dr. Fleming oversaw clinical review of the earliest biotech products including human insulin and growth hormone. He helped to shape FDA policies and practices related to therapeutic review and regulatory communication. He was a major contributor to FDA's Good Review Practice (GRP) initiative and led the committee responsible for education and training at CDER. He conceived and directed the first FDA pilot project to utilize the internet for regulatory communication.His regulatory and technical expertise has been requested in numerous international settings including the World Health Organization, where he was assigned from FDA during 1991-92. Dr. Fleming was a member of the expert working groups on Good Clinical Practices and General Considerations for Clinical Trials of the International Conference on Harmonization (ICH) and participated on other ICH committees including the Common Technical Document working group.Dr. Fleming is lead author of the book, Optimizing Development of Therapies for Diabetes.
He has frequently published scientific articles and book chapters, the most recent chapter, Regulatory Considerations for Early Clinical Development, is in Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development, published by Springer in October 2018. He has been a member of many corporate and advisory boards to academic and commercial institutions and professional societies. He serves on the joint technology working groups of the European Association for the Study of Diabetes and American Diabetes Association.Dr. Fleming coined the term, Metabesity, which refers to the constellation of cancer, heart and neurologic diseases, diabetes and the aging process itself, all which share common metabolic root causes and potential preventive therapies. He organized the first Congress on Metabesity in London in October 2017, which will be followed by the second Congress in Washington, D.C. in 2019.

Edd Fleming, MD

Edd Fleming, MD, is a Senior Partner at McKinsey and Company in the Silicon Valley Office in Redwood City, CA. He earned his BA in Chemistry from Harvard, his MD from Vanderbilt University, and completed internal medicine training at Johns Hopkins Hospital and subspecialty training in pulmonary and critical care medicine at the University of California, San Fran-cisco. He joined McKinsey and Company in 1997 where he has focused on healthcare. He works closely with life sciences, biopharmaceutical, medical device and technology companies of all sizes to improve their performance. This support includes business plan development, strategy, operational performance, organization and business development. He spends half of his time working directly with the innovation side of these companies improving R&D productivity through supporting decisions about innovation, portfolio management, novel approaches to trial design and execution, application of digital and analytics, and improving the culture and ways of working. He is the global leader of McKinsey's R&D practice where he is responsible for its client service and knowledge development on R&D topics. In that role, he founded the Chief Medical Officers' and Medical Affairs' forums where senior leaders across industry gather several times a year. He is the author of multiple recent publications, including The Value of Medical: Enhancing Patient Benefit, Digital R&D: The Next Frontier for Biopharmaceuticals, Precision Medicine: Opening the Aperture, and R&D in the Age of Agile. He is currently working closely with the newly formed national Physician Scientist Support Foundation to increase the number of physicians engaging in research.

Yiu-Lian Fong, MS, MBA, PhD

Yiu-Lian Fong, MS, MBA, PhD, is the Global Head for Diagnostic Innovation, Research and Early Development at Johnson & Johnson Innovation.Yiu-Lian has global responsibility for identifying, assessing and accelerating the development of breakthrough diagnostic technologies and solutions to help drive precision medicine and Johnson & Johnson's World Without Disease initiative.Prior to joining Johnson & Johnson Innovation, Yiu-Lian was the Divisional Vice President for R&D at Abbott Molecular. In this position, she was responsible for R&D strategic oversight, menu expansion, advancing R&D pipelines including the development of next generation molecular diagnostic platform technologies. Previously, she was the Executive Director of Molecular Diagnostics and Companion Diagnostics Development at Novartis Oncology. Yiu-Lian brings a broad and extensive background in the pharmaceutical and biotechnology industries including experience in technology and product development, blood testing/screening, vaccines and IVD Immuno and molecular diagnostics, as well as therapeutic drug/vaccine development.Yiu-Lian received her M.S. in Life Sciences from The National Tsing Hua University in Taiwan, and her MBA from the University of Massachusetts, Amherst. She earned her Ph.D. in Molecular Physiology and Biophysics from Vanderbilt University and was a post graduate fellow at Johns Hopkins University. Yiu-Lian also has 25 publications in peer review journals and several issued patent applications.

Sarah Hymowitz, PhD

Sarah Hymowitz, Ph.D. joined The Column Group in 2021. Previously, she spent 22 years at Genentech rising to Vice President of Protein Sciences. In this role, she oversaw the large molecule drug discovery portfolio and mentored project teams on the identification and optimization of more than 35 clinical candidates.Earlier, as a member of the Genentech Small Molecule Leadership Team, she supported teams in advancing more than 25 molecules to IND-enabling studies and led a collaboration with AbbVie and the Walter and Eliza Hall Institute that resulted in the discovery of Venclexta.Dr. Hymowitz earned a B.A. in Chemistry from Swarthmore College, followed by a Ph.D. in Biophysics from the University of California, San Francisco prior to joining Genentech in 1999 as a postdoctoral fellow.She is on the Board of Directors of InduPro and on the Scientific Advisory Board of Surrozen.

Richard Hamilton, PhD

Richard Hamilton, PhD, is the co-founder, President and CEO of Prosper eDNA, a technology startup company focused on a consumer-based product that analyzes epigenetics to provide personalized recommendations on diet, exercise, mindfulness and aging. Before Prosper, Dr. Hamilton was the President and CEO of Ceres, Incorporated, a publicly held plant genomics company that was acquired by Land O'Lakes.Dr. Hamilton has more than 20 years of experience in biotechnology, genomics and finance. He served as Principal of Oxford Bioscience Partners, one of the leading investors in the genomics field. He has been active in the Biotechnology Industry Organization, where he has served as Vice Chairman of the organization, chaired its Food and Agriculture Governing Board and served in other leadership roles. He has been a member of the Keck Graduate Institute Advisory Council and was a Founding Member of the Council for Sustainable Biomass Production. He frequently speaks before policymakers, business leaders and scientific organizations regarding biotechnology and genomics. He has addressed the House Agriculture Committee, the President's Council of Advisors on Science and Technology and the National Academy of Sciences, among others. He has been a Director of Yield10 Bioscience, Incorporated, since March 2, 2017. From 1990 to 1991, he served as a Howard Hughes Medical Institute Research Fellow of Harvard Medical School.

Renee Bailey Iacona, PhD, MPH

Renee Bailey Iacona, PhD, MPH, is the VP and Head of Biometrics Oncology, R&D Oncology Unit, at AstraZeneca Pharmaceuticals. Renee joined AstraZeneca in 2001 and during her time here has experience of working across both early and late Oncology, as Global Product Statistician, Line Manager, Alliance Director and Section Director for Stats & Programming (Wilmington and Sodertalje) before serving as Head of Alliance & Operations for Biometrics & Information Sciences. Since 2015, she has been the B&I TA Head for Oncology and Immuno-Oncology and an active member of the Oncology Development Review Committee, Oncology Therapy Area Leadership Team and Cancer Enterprise. Renee earned her PhD in Pathology and MPH from Vanderbilt University. She currently co-chairs an external cross-Pharma initiative with the FDA looking into the effects of Non-Proportional Hazards on the design and interpretation of Oncology Trials.

Clayton Knox, MD, MBA

Clayton Knox, MD, MBA, has more than a decade of experience in biotech executive leadership, business development, and clinical research. Prior to VelosBio, he served as Chief Operating Officer at MavuPharma where he was responsible for all aspects of day-to-day management and led the company through an acquisition by AbbVie. Before MavuPharma, Dr. Knox was Senior Vice President and Head of Corporate Development and Strategy at Acerta Pharma where he led the business development process that concluded with the acquisition of Acerta by AstraZeneca for up to $7 billion. Following the transaction, he led the integration of the two companies, while continuing to oversee all corporate and business development activities. Before making the move to biotech, Dr. Knox was an executive at Merck & Co., most recently as Clinical Head for Business Development and Licensing where he was responsible for search-and-evaluation and transactions for strategic, clinical-stage assets. He previously served as Principal Scientist and Director of Clinical Research, and led the early clinical development of several Merck drug candidates, including the oversight of solid tumor and hematologic cancer clinical trials.Dr. Knox completed his MD at Vanderbilt University School of Medicine where he was a Dean's Scholar and an Alpha Omega Alpha Research Fellow, followed by internship and residency in internal medicine at Massachusetts General Hospital. He also received an MBA from The Wharton School of the University of Pennsylvania.

Lee E. Limbird, PhD

Lee E. Limbird, PhD, obtained her undergraduate degree in Chemistry from the College of Wooster, Wooster, Ohio in 1970, and her PhD in Biochemistry from the University of North Carolina, Chapel Hill, in 1973. Her PhD research was in a directly clinically applicable area, the quantitation of the isoenzymes of CPK for identification of myocardial infarction in the context of confounding ECG findings. However, a postdoctoral fellowship with Robert J. Lefkowitz, MD, Duke University, transitioned her research focus to basic science research and to the molecular bases for epinephrine action through G protein-coupled receptors. Her own laboratory at Vanderbilt University (1979-2014) focused on the affinity purification and identification of interacting partners for the alpha2-adrenergic receptor, and functional consequences in vitro and in vivo of mutation of the receptor to selectively disrupt coupling to one versus another signaling pathway. The laboratory also investigated the underlying molecular bases for receptor trafficking to distinct compartments in polarized cells. Her laboratory has been the recipient of many research awards.As Chair of Pharmacology at Vanderbilt University, Dr. Limbird enjoyed the privilege of mentoring junior faculty in their career development; as the first Associate Vice Chancellor for Research at Vanderbilt Medical Center, Dr. Limbird fostered a focus on inter-disciplinary collaboration and discovery acceleration via establishment of critical Core Facilities for biomedical research. After retiring from Vanderbilt University in 2004, Dr. Limbird pursued in more depth her commitment to developing greater opportunities for those currently underrepresented in discovery and in scientific leadership via her roles first at Meharry Medical College (Vice President for Research and Chair of Biomedical Sciences) and now at Fisk University as Dean, School of Natural Science, Mathematics and Business & Professor, Department of Life and Physical Sciences.

Laura Niedernhofer, MD, PhD

Laura Niedernhofer, MD, PhD, joined the University of Minnesota in 2018 to direct a new Institute on the Biology of Aging & Metabolism. She is also a Professor in the Department of Biochemistry, Molecular Biology and Biophysics at UMN. Laura studied chemistry at Duke University and completed the medical scientist training program at Vanderbilt University School of Medicine earning a PhD in Biochemistry.Prior to moving to Minneapolis, Laura was at The Scripps Research Institute, where she helped spearhead identification of a new class of drugs called senolytics, which selectively kill senescent cells. Dr. Niedernhofer's expertise is in DNA damage and repair, progeroid syndromes, cellular senescence and aging. Her research contributed to the understanding that DNA damage plays a causal role in senescence and aging. Laura has been awarded for her research in aging, cancer and environmental health science and was the 2018 recipient of the Vincent Cristafolo Rising Star in Aging Research awarded by the American Federation for Aging Research.

William Pao, MD, PhD

Dr. William Pao, MD, PhD, is Chief Development Officer and Executive Vice President for Pfizer. He leads the Global Product Development organization, which is responsible for the clinical development and advancement of Pfizer's pipeline of innovative medicines in inflammation and immunology, internal medicine, hospital, oncology, rare disease, and vaccines, as well as regulatory affairs in support of Pfizer's R&D pipeline and portfolio of marketed medicines and vaccines.Prior to joining Pfizer in 2022, William served as the Head of Roche Pharma Research & Early Development (pRED), where he oversaw the discovery and early development of a portfolio of new molecular entities to treat diseases related to cancer, neuroscience, ophthalmology, rare diseases, immunology, infectious diseases, and rare blood disorders, across seven global sites. He was also a member of Roche's Enlarged Corporate Executive Committee.Before joining Roche, he simultaneously held key positions of Professor of Medicine and Director of the Division of Hematology/Oncology at Vanderbilt University, and Director of Personalized Cancer Medicine at Vanderbilt-Ingram Cancer Center.William is recognized for his ground-breaking work in translational medicine, mechanistic and clinical studies of targeted cancer therapeutics, and for his leadership in cancer genomics and personalized medicine. His laboratory work identiﬁed new molecular mechanisms of sensitivity and resistance of lung cancers to EGFR tyrosine kinase inhibitors (TKIs), yielded important insights into a molecular understanding of lung cancer and other malignancies, and led to the development of multiple therapeutics to treat lung cancer. The author of multiple scientiﬁc and medical publications, William has served as an advisor to numerous professional associations including the National Cancer Institute (NCI), the American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO) and has served on the editorial boards of prestigious medical research journals including Cancer Discovery, Cancer Research, Clinical Cancer Research, and the Journal of Clinical Oncology. William also co-founded MyCancerGenome, an internationally recognized online tool to enable a genetically informed approach to cancer medicine. He currently serves as co-chair of the Executive Committee of the NIH Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) public-private partnership and on the Boards of TransCelerate and the American Association for Cancer Research. He was inducted to the American Society for Clinical Investigation in 2011 and the Association of American Physicians in 2017.William received his undergraduate degree from Harvard, and his M.D. and Ph.D. degrees from Yale University. Following his residency training in Internal Medicine at New York-Presbyterian Hospital/Weill-Cornell Medical School Campus, he completed his medical oncology and postdoctoral fellowship at Memorial Sloan-Kettering Cancer Center, where he joined the faculty.

Asit Parikh, MD, PhD

Asit Parikh, MD, PhD, earned his Ph.D in Biochemistry and MD degrees from Vanderbilt University, completed internal medicine residency at the University of Pennsylvania, and subspecialty training in gastroenterology at the Massachusetts General Hospital, with postdoctoral work in Cancer Biology at MIT. In February 2021, Dr. Parikh was appointed President and Chief Executive Officer of MOMA Therapeutics, a biopharmaceutical company.Prior to MOMA, Dr. Parikh served as senior vice president and head of Takeda's gastroenterology unit since 2012. Under his leadership, Takeda has achieved global approvals for Entyvio® for ulcerative colitis and Crohn's disease, European adult and U.S. pediatric approvals for Gattex®/Revestive® for short bowel syndrome, Japan and China approvals for Takecab®/Vocinti® for acid related disorders, a European approval for Alofisel® for perianal fistulizing Crohn's disease, and a U.S. approval for Motegrity® for chronic constipation. Prior to Takeda, he worked in the clinical research division at Millennium Pharmaceuticals, where he held leadership roles in inflammation and oncology drug development. Dr. Parikh remains actively engaged in the practice of medicine as a consulting gastroenterologist at Newton-Wellesley Hospital in Newton, Mass., and serves as a board member of Ambys Medicines, and Phathom Pharmaceuticals.Dr. Parikh maintains a commitment to research, patient care and teaching. He has authored a number of scientific manuscripts and presented at major scientific congresses. He continues to teach graduate students and residents as a guest lecturer, and is board certified and licensed to practice internal medicine and gastroenterology in the state of Massachusetts.

Colleen Elizabeth Piersen, PhD

Colleen Elizabeth Piersen, PhD, currently holds the position of Assistant Head for Administration and Research Assistant Professor of Pharmacognosy in the Department of Pharmaceutical Sciences in the College of Pharmacy at the University of Illinois at Chicago (UIC). She also serves in the role of Director of Research Services at the College level. Dr. Piersen has over twenty years of experience as a researcher, faculty member, or academic professional at four major research universities and one biotechnology company. Her biomedical background is broad having conducted and/or managed basic through translational research in the fields of G-protein coupled receptors, DNA repair, reproductive health, and botanical dietary supplements. Much of her research activity has focused on women's health, especially during her tenure as Program Coordinator for the UIC/NIH Center for Botanical Dietary Supplements Research.Colleen currently serves as the principal staff administrator in the Department of Pharmaceutical Sciences, and while she specializes in sponsored research administration, her responsibilities span research, finance, academic/faculty affairs, space, and human resources management. She has provided key administrative support for the establishment of two Board of Trustees-approved centers: the UIC/NIH Center for Botanical Dietary Supplements Research (1999 - present) and the UICentre for Drug Discovery (2012 - present). From 2015-2017, Dr. Piersen held the elected role of Chair of the UIC Academic Professional Advisory Committee (APAC).She concurrently served as Chair of the University [of Illinois] System Professional Personnel Advisory Committee (UPPAC) from 2015-2016. More recently, she was selected to participate in the 2018-2019 UI Academic Professional Leadership Program. Dr. Piersen holds a BA in Chemistry from Carleton College, a PhD in Pharmacology from Vanderbilt University, and an MBA in Healthcare Administration from Alaska Pacific University.

Mace Rothenberg, MD

As the former Chief Medical Officer of Pfizer, Mace Rothenberg, MD, led Pfizer's Worldwide Medical & Safety organization that is responsible for ensuring that patients, physicians, and regulatory agencies are provided with information on the safe and appropriate use of Pfizer medications. Dr. Rothenberg was also a member of Pfizer's Portfolio Strategy and Investment Committee, Worldwide Research, Development, and Medical Leadership Team, and Blueprint Leaders Forum. Dr. Rothenberg co-chairs the Life Sciences Consortium of the CEO Roundtable on Cancer and is a member of the NYU School of Medicine's Alumni Board of Governors.Prior to becoming Pfizer's CMO, Dr. Rothenberg was Head of Clinical Development & Medical Affairs for Oncology from 2008 to 2016 and Chief Development Officer for Oncology from 2016 to 2018, During that period, Dr. Rothenberg's organization was responsible for the successful development and regulatory approval of 11 new cancer medicines. Prior to joining Pfizer, Dr. Rothenberg spent 25 years in academia where he focused on early-stage drug development, clinical trial design, and the coordinated laboratory-clinical evaluation of new therapies for gastrointestinal cancers.Dr. Rothenberg is the recipient of the first Craig Saxton Lifetime Achievement Award from Pfizer, the Lane W. Adams Quality of Life Award from the American Cancer Society honoring him as one of the nation's top cancer caregivers, and the Statesman Award from the American Society of Clinical Oncology honoring him for more than 20 years of service to the organization, the specialty of oncology and cancer patients. He is a Fellow of the American College of Physicians and the American Society of Clinical Oncology.Dr. Rothenberg received his BA magna cum laude from the University of Pennsylvania in 1978 and his MD from the New York University School of Medicine in 1982. He received his post-graduate training in Internal Medicine at Vanderbilt University and in Medical Oncology at the National Cancer Institute. Dr. Rothenberg served on the faculties of the University of Texas Health Science Center-San Antonio (1991-1998) and Vanderbilt University (1998-2008).

Lori Rudolph-Owen

Lori Rudolph-Owen, Ph.D. is an accomplished C-suite biotech executive and board member, with over 26 years of biotech and pharma experience. She is currently serving as an IND and Development Consultant to early stealth venture backed biotech companies, as well as serving on the Board of Directors for Codagenix, Inc.

Previously, Lori served as the Chief Operating Officer of Senda Biosciences, an emerging Flagship biotech company, leading operations of the R&D and platform functions and developing Senda’s clinical trials and regulatory capabilities. Prior to joining Senda, Lori was the Chief Development Officer at Goldfinch Bio where she was accountable for the strategic development and operational execution of the portfolio. Lori built the development organization from the ground up and drove GFB-887, a small molecule Trpc5 inhibitor, and GFB-024, a monoclonal CB-1 inverse agonist, from late-stage discovery through IND submission and into Ph2 proof of concept clinical development. While at Goldfinch, Lori was an integral member of the Executive Team responsible for the adjustment of the portfolio and optionality considerations for financing and strategic alternatives.

Prior to Goldfinch, Lori served as Vice President of Portfolio Management and Assessment at TESARO, Inc., where she built and led the portfolio development teams responsible for the US and EU submissions and approvals of VARUBI® and ZEJULA®, as well as the filing of multiple investigational new drug (IND) applications. Before TESARO, Lori held positions of increasing leadership responsibility at Pfizer, AMAG Pharmaceuticals, MGI Pharma (now Eisai), Vertex and Millennium. Lori received her B.A. in Biology from Carroll University and her Ph.D. in Cell Biology from Vanderbilt University’s School of Medicine as well as completing a postdoctoral fellowship in the Department of Biochemistry also at Vanderbilt University School of Medicine.

J. Joshua Smith, MD, PhD, FACS

J. Joshua Smith, MD, PhD, FACS, is a clinician-scientist specializing in basic and translational colorectal cancer research. His efforts are directed entirely toward the treatment of patients with rectal and colon cancer. In his R01-funded laboratory, he works to understand the molecular underpinnings of disease progression and to develop individualized disease models that will facilitate both effective research and precision treatment for rectal cancer patients.During his general surgery training at Vanderbilt University, he completed a PhD in cell and developmental biology. After finishing training at Vanderbilt, he completed a fellowship in surgical oncology with an emphasis in colon and rectal cancer at Memorial Sloan Kettering Cancer Center (MSK), where he served as Chief Administrative Fellow for the Department of Surgery. He is an Assistant Member and board-certified Attending Surgeon on the Colorectal Service at MSK. He serves as core faculty for the MSK Surgical Oncology Fellowship. The majority of his time is devoted to basic and translational research. He leverages the strengths of MSK, including the high volume of rectal cancer patients treated by the Colorectal Service (>350/year) and the opportunity to run clinical trials.He is an active co-investigator in the randomized trial integrating non-operative management for selected patients with rectal cancer (NCT02008656). He is also the junior lead on a national trial investigating non-operative management in patients with rectal cancer through the Alliance for Clinical Trials in Oncology. Additionally, he serves on the Rectal-Anal Task Force of the National Cancer Institute's Gastrointestinal Steering Committee, and is a co-PI on a phase IB trial investigating a novel radiosensitizer to improve clinical responses for patients with rectal cancer. His chief objective as a clinician and scientist is to uncover more precise treatments for each individual rectal cancer patient.