Liver Disease Research

Liver Disease

Liver disease affects millions globally, with causes including fatty liver (MASLD), viral hepatitis (HCV/HBV), alcohol, and obesity, leading to significant mortality (2M deaths/year globally) and disability. Vanderbilt University School of Medicine Basic Sciences researchers investigate the molecular and cellular mechanisms underlying human liver diseases, from fatty liver and hepatitis to fibrosis and liver cancer. Using genetics, cell biology, immunology, and cutting-edge technologies such as single-cell analysis and organoid models, teams uncover pathways that drive injury, inflammation, and regeneration. Their work aims to identify new biomarkers and therapeutic targets, advancing translational discoveries that improve diagnosis and treatment for patients with liver disease.