AlphaFold

Alexandra C. Schwartz, a recent Ph.D. graduate from the Chemical and Physical Biology Program, and colleagues developed an experimental and artificial intelligence–coupled methodology to explore the structural dynamics of membrane proteins. Read More

Dr. Jumper’s work with AlphaFold2 represents an unprecedented step in the integration of artificial intelligence and the natural sciences. John and his colleagues have given us inspiring evidence of its limitless potential for advancing scientific discovery. Read More

Benjamin P. Brown, assistant professor of pharmacology, and colleagues in the departments of molecular physiology and biophysics, pharmacology, and chemistry, have determined that AlphaFold2 can be used to generate approximations of relative conformational preferences of proteins, which will help researchers better understand a protein’s structure and function across a range of conditions and mutational states. Read More

The Aug. 30 School of Medicine Basic Sciences Apex Lecture featured visionary biophysicist John Jumper (BS’07). His talk described AlphaFold, the revolutionary protein structure-predicting program, that he co-developed. Read More

John Jumper, Ph.D. To highlight major inflection points in research, the Vanderbilt School of Medicine Basic Sciences launched the Apex Lecture Series earlier this year, which allows the Basic Sciences community to engage with researchers from around the world who are influencing the trajectory of their fields. John… Read More